Seroatlas · Human Serome Atlas

CCDC61

Centrosomal protein CCDC61

Also known as: CCD61_HUMAN, hVFL3, VFL3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6R9
Gene
CCDC61
Ensembl
ENSG00000104983
Chromosome
19
Canonical length
512 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables identical protein binding activity and microtubule binding activity. Involved in centriole assembly and mitotic spindle assembly. Located in centriolar satellite and ciliary basal body. Part of centriolar subdistal appendage. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>Q9Y6R9|CCDC61
     1  MDQPAGLQVD YVFRGVEHAV RVMVSGQVLE LEVEDRMTAD QWRGEFDAGF IEDLTHKTGN
    61  FKQFNIFCHM LESALTQSSE SVTLDLLTYT DLESLRNRKM GGRPGSLAPR SAQLNSKRYL
   121  ILIYSVEFDR IHYPLPLPYQ GKPDPVVLQG IIRSLKEELG RLQGLDGQNT RDTRENEIWH
   181  LREQVSRLAS EKRELEAQLG RSREEALAGR AARQEAEALR GLVRGLELEL RQERGLGHRV
   241  AGRRGQDCRR LAKELEEAKA SERSLRARLK TLTSELALYK RGRRTPPVQP PPTREDRASS
   301  SRERSASRGR GAARSSSRES GRGSRGRGRP ARPSPSPTGG RALRFDPTAF VKAKERKQRE
   361  IQMKQQQRNR LGSGGSGDGP SVSWSRQTQP PAALTGRGDA PNRSRNRSSS VDSFRSRCSS
   421  ASSCSDLEDF SESLSRGGHR RRGKPPSPTP WSGSNMKSPP VERSHHQKSL ANSGGWVPIK
   481  EYSSEHQAAD MAEIDARLKA LQEYMNRLDM RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC61 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • testis: 24 nTPM
  • fallopian tube: 14 nTPM
  • spleen: 13 nTPM
  • pituitary gland: 13 nTPM
  • kidney: 12 nTPM
  • liver: 12 nTPM

Single-cell type

  • oocytes: 28 nCPM
  • melanocytes: 25 nCPM
  • fallopian tube ciliated cells: 23 nCPM
  • respiratory ciliated cells: 20 nCPM
  • neutrophil progenitors: 17 nCPM
  • cytotrophoblasts: 15 nCPM

Immune cell

  • basophil: 6.5 nTPM
  • neutrophil: 1.3 nTPM
  • naive B-cell: 1.2 nTPM
  • gdT-cell: 0.9 nTPM
  • memory B-cell: 0.8 nTPM
  • naive CD4 T-cell: 0.6 nTPM

Brain region

  • cerebellum: 35 nTPM
  • cerebral cortex: 28 nTPM
  • basal ganglia: 24 nTPM
  • hippocampal formation: 22 nTPM
  • white matter: 22 nTPM
  • amygdala: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.44
gnomAD pLI
0
gnomAD missense Z
0.61
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 61, N-terminal head domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC61 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC61 as an antibody target. Whether an autoantibody or antibody against CCDC61 could matter depends on whether native CCDC61 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC61 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC61 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC61. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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