Seroatlas · Human Serome Atlas

TEKT2

Tektin-2

Also known as: TEKT2_HUMAN, TEKTB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UIF3
Gene
TEKT2
Ensembl
ENSG00000092850
Chromosome
1
Canonical length
430 aa
Protein class
Predicted intracellular proteins
Subcellular location
Connecting piece,Flagellar centriole,Mid piece,Principal piece

OverviewNCBI Gene

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>Q9UIF3|TEKT2
     1  MATLSVKPSR RFQLPDWHTN SYLLSTNAQL QRDASHQIRQ EARVLRNETN NQTIWDEHDN
    61  RTRLVERIDT VNRWKEMLDK CLTDLDAEID ALTQMKESAE QNLQAKNLPL DVAIECLTLR
   121  ESRRDIDVVK DPVEDELHKE VEVIEATKKA LQQKVSQAFE QLCLLQEVQQ QLNSDHRGKM
   181  ETLEIDRGCL SLNLRSPNIS LKVDPTRVPD GSTTLQQWDD FSRFNKDRAE AEMKAATELR
   241  EATALTIAET NNELEAQRVA TEFAFRKRLR EMEKVYSELK WQEKNTLEEI AELQEDIRHL
   301  EEDLRTKLLS LKLSHTRLEA RTYRPNVELC RDQAQYGLTD EVHQLEATIA ALKQKLAQAQ
   361  DALDALCKHL ARLQADIACK ANSMLLDTKC MDTRRKLTVP AERFVPEVDT FTRTTNSTLS
   421  PLKSCQLELA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEKT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • testis: 69 nTPM
  • fallopian tube: 59 nTPM
  • choroid plexus: 27 nTPM
  • lung: 6.5 nTPM
  • hypothalamus: 4.8 nTPM
  • pituitary gland: 4.4 nTPM

Single-cell type

  • early spermatids: 567 nCPM
  • late spermatids: 458 nCPM
  • late primary spermatocytes: 278 nCPM
  • fallopian tube ciliated cells: 250 nCPM
  • respiratory ciliated cells: 199 nCPM
  • epididymal efferent duct ciliated cells: 90 nCPM

Immune cell

  • neutrophil: 1.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 24 nTPM
  • midbrain: 11 nTPM
  • medulla oblongata: 7.6 nTPM
  • spinal cord: 6.6 nTPM
  • pons: 4.2 nTPM
  • white matter: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
-0.51
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEKT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEKT2 as an antibody target. Whether an autoantibody or antibody against TEKT2 could matter depends on whether native TEKT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEKT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEKT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEKT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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