Seroatlas · Human Serome Atlas

CCDC120

Coiled-coil domain-containing protein 120

Also known as: CC120_HUMAN, JM11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96HB5
Gene
CCDC120
Ensembl
ENSG00000147144
Chromosome
X
Canonical length
630 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a protein that contains a coiled-coil domain. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>Q96HB5|CCDC120
     1  MEVKGQLISS PTFNAPAALF GEAAPQVKSE RLRGLLDRQR TLQEALSLKL QELRKVCLQE
    61  AELTGQLPPE CPLEPGERPQ LVRRRPPTAR AYPPPHPNQA HHSLCPAEEL ALEALEREVS
   121  VQQQIAAAAR RLALAPDLST EQRRRRRQVQ ADALRRLHEL EEQLRDVRAR LGLPVLPLPQ
   181  PLPLSTGSVI TTQGVCLGMR LAQLSQEDVV LHSESSSLSE SGASHDNEEP HGCFSLAERP
   241  SPPKAWDQLR AVSGGSPERR TPWKPPPSDL YGDLKSRRNS VASPTSPTRS LPRSASSFEG
   301  RSVPATPVLT RGAGPQLCKP EGLHSRQWSG SQDSQMGFPR ADPASDRASL FVARTRRSNS
   361  SEALLVDRAA GGGAGSPPAP LAPSASGPPV CKSSEVLYER PQPTPAFSSR TAGPPDPPRA
   421  ARPSSAAPAS RGAPRLPPVC GDFLLDYSLD RGLPRSGGGT GWGELPPAAE VPGPLSRRDG
   481  LLTMLPGPPP VYAADSNSPL LRTKDPHTRA TRTKPCGLPP EAAEGPEVHP NPLLWMPPPT
   541  RIPSAGERSG HKNLALEGLR DWYIRNSGLA AGPQRRPVLP SVGPPHPPFL HARCYEVGQA
   601  LYGAPSQAPL PHSRSFTAPP VSGRYGGCFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC120 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 35 nTPM
  • skin: 28 nTPM
  • vagina: 15 nTPM
  • cervix: 13 nTPM
  • cerebellum: 12 nTPM
  • salivary gland: 11 nTPM

Single-cell type

  • esophageal apical cells: 115 nCPM
  • esophageal suprabasal cells: 54 nCPM
  • syncytiotrophoblasts: 30 nCPM
  • enterocytes: 29 nCPM
  • suprabasal keratinocytes: 29 nCPM
  • ocular epithelial cells: 26 nCPM

Immune cell

  • basophil: 1.1 nTPM
  • neutrophil: 1 nTPM
  • naive B-cell: 0.6 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • eosinophil: 0.5 nTPM
  • memory CD4 T-cell: 0.4 nTPM

Brain region

  • cerebellum: 16 nTPM
  • basal ganglia: 11 nTPM
  • hypothalamus: 11 nTPM
  • cerebral cortex: 11 nTPM
  • amygdala: 11 nTPM
  • choroid plexus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.43
gnomAD missense Z
0.07
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC120 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC120 as an antibody target. Whether an autoantibody or antibody against CCDC120 could matter depends on whether native CCDC120 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC120 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC120 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC120. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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