CDKN2C

Protein identityUniProt · HPA

UniProt accession

P42773

Gene

CDKN2C

Ensembl

ENSG00000123080

Chromosome

1

Canonical length

168 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

168 residues, UniProt reviewed canonical sequence.

>P42773|CDKN2C
     1  MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG
    61  ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED NEGNLPLHLA AKEGHLRVVE
   121  FLVKHTASNV GHRNHKGDTA CDLARLYGRN EVVSLMQANG AGGATNLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDKN2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

92 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDKN2C.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 30 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Multiple myeloma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.95

gnomAD pLI

0.4

gnomAD missense Z

1.08

DepMap mean gene effect

0.28

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of cell growth
• negative regulation of cell population proliferation
• negative regulation of stem cell proliferation
• oligodendrocyte differentiation
• regulation of G1/S transition of mitotic cell cycle
• stem cell proliferation

Molecular functions

• cyclin-dependent protein serine/threonine kinase inhibitor activity
• protein kinase binding

Cellular components

• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Ankyrin repeat
• Ankyrin repeat-containing domain superfamily
• Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor
• Ankyrin repeats (3 copies)
• Ankyrin repeats (many copies)

KeywordsUniProt

• ANK repeat
• Cell cycle
• Repeat

InteractionsUniProt · HPA

Protein binding partners of CDKN2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CCND1
• CDK4
• CDK6