CDKN2D

Protein identityUniProt · HPA

UniProt accession

P55273

Gene

CDKN2D

Ensembl

ENSG00000129355

Chromosome

19

Canonical length

166 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>P55273|CDKN2D
     1  MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM FGSTAIALEL
    61  LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV NVPDGTGALP IHLAVQEGHT
   121  AVVSFLAAES DLHRRDARGL TPLELALQRG AQDLVDILQG HMVAPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDKN2D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

268 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.39

gnomAD pLI

0.49

gnomAD missense Z

1.13

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• autophagic cell death
• DNA synthesis involved in DNA repair
• negative regulation of cell growth
• negative regulation of cell population proliferation
• negative regulation of G1/S transition of mitotic cell cycle
• negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
• regulation of G1/S transition of mitotic cell cycle
• response to retinoic acid
• response to UV
• response to vitamin D
• sensory perception of sound

Molecular functions

• cyclin-dependent protein serine/threonine kinase inhibitor activity
• protein kinase binding

Cellular components

• cyclin D2-CDK4 complex
• cytoplasm
• cytosol
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Ankyrin repeat
• Ankyrin repeat-containing domain superfamily
• Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor
• Ankyrin repeats (3 copies)

KeywordsUniProt

• Acetylation
• ANK repeat
• Cell cycle
• Cytoplasm
• Nucleus
• Repeat
• Tumor suppressor

InteractionsUniProt · HPA

Protein binding partners of CDKN2D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDK6
• CDK4