Seroatlas · Human Serome Atlas

KIAA1671

Uncharacterized protein KIAA1671

Also known as: K1671_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY89
Gene: KIAA1671
Ensembl: ENSG00000197077
Chromosome: 22
Canonical length: 1806 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Primary cilium

OverviewNCBI Gene

Located in cilium; intercellular bridge; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1806 residues, UniProt reviewed canonical sequence.

>Q9BY89|KIAA1671
     1  MATRVEVGSI TPLTAVPGLG EMGKEETLTR TYFLQAGEAS GAPPARILEA KSPLRSPARL
    61  LPLPRLAPKP FSKEQDVKSP VPSLRPSSTG PSPSGGLSEE PAAKDLDNRM PGLVGQEVGS
   121  GEGPRTSSPL FNKAVFLRPS SSTMILFETT KSGPALGKAV SEGAEEAKLG VSGSRPEVAA
   181  KPALPTQKPA GTLPRSAPLS QDTKPPVPQE EAGQDHPPSK ASSVEDTARP LVEPRPRLKR
   241  RPVSAIFTES IQPQKPGPGA AATVGKVPPT PPEKTWVRKP RPLSMDLTAR FENKEALLRK
   301  VADEGSGPTA GDMAGLERPR AASKLDRDCL VKAEAPLHDP DLDFLEVAKK IRERKEKMLS
   361  KPEMGSPRAL VGGSSGVTPS NDQSPWEEKA KLDPEPEKAA ESPSPRLGRG LELAEVKSRV
   421  ADGEAAAGGE WASRRSVRKC ISLFREDSTL ALAVGSESPL ATPASPSAAP EPEKGVVSVQ
   481  ERIRGWTAES SEAKPEVRRR TFQARPLSAD LTKLFSSSAS SNEVKYEKSA ELSGEFPKEP
   541  REKQKEGHSL DGACIPRSPW KPGTLRDKSR QTEQKVSSNQ DPDSCRGGSS VEAPCPSDVT
   601  PEDDRSFQTV WATVFEHHVE RHTVADQSGR CLSTTPPGDM AHARVSEPRP RPEMGSWLGR
   661  DPPDMTKLKK ENSRGFDNPE TEKLGPTTLL NGELRPYHTP LRDKYPLSEN HNNNTFLKHL
   721  ENPPTSQRIE PRYDIVHAVG ERVHSEAISP APEEKAVTLR SLRSWLSLKD RQLSQEVTPA
   781  DLECGLEGQA GSVQRASLIW EARGMPEASG PKFGGNCPFP KWTGGAVVSS HKATVAVSEE
   841  HCAPGATSVR AIKAAIWESQ HEGPEGARSK PGVGARGPPQ GCPLDPLSRA TNGPSDSQAR
   901  THPDAFAVQK GPFIVAAREG DPGPAQVPQP AVRMRKAGAM DQRMDRWRRR TLPPNVKFDT
   961  FSSLVPEDSP HVGHRRTDYV SPTASALRKP QLSHYRVETQ EVNPGASRDQ TSPAVKQGSP
  1021  VEPKATFFAV TYQIPNTQKA KGVVLSGAES LLEHSRKITP PSSPHSLTST LVSLGHEEAL
  1081  EMAGSKNWMK GREHENASIL KTLKPTDRPS SLGAWSLDPF NGRIIDVDAL WSHRGSEDGP
  1141  RPQSNWKESA NKMSPSGGAP QTTPTLRSRP KDLPVRRKTD VISDTFPGKI RDGYRSSVLD
  1201  IDALMAEYQE LSLKVPGEAQ ERRSPTVEPS TLPRERPVQL GGVEQRRRSL KEMPDTGGLW
  1261  KPASSAEINH SFTPGLGKQL AETLETAMGT KSSPPFWALP PSAPSERYPG GSPIPADPRK
  1321  KTGFAEDDRK AFASKHHVAK CQNYLAESKP SGREDPGSGV RVSPKSPPTD QKKGTPRKST
  1381  GRGEEDSVAQ WGDHPRDCGR VPLDIKRAYS EKGPPANIRE GLSIMHEARE RRREQPKGRP
  1441  SLTGENLEAK MGPCWWESGT GDSHKVLPRD LEKEDAPQEK ERPLQQVSPV ASVPWRSHSF
  1501  CKDRRSGPFV DQLKQCFSRQ PTEPKDTDTL VHEAGSQYGT WTEQCQSGES LATESPDSSA
  1561  TSTRKQPPSS RLSSLSSQTE PTSAGDQYDC SRDQRSTSVD HSSTDLESTD GMEGPPPPDA
  1621  CPEKRVDDFS FIDQTSVLDS SALKTRVQLS KRSRRRAPIS HSLRRSRFSE SESRSPLEDE
  1681  TDNTWMFKDS TEEKSPRKEE SDEEETASKA ERTPVSHPQR MPAFPGMDPA VLKAQLHKRP
  1741  EVDSPGETPS WAPQPKSPKS PFQPGVLGSR VLPSSMDKDE RSDEPSPQWL KELKSKKRQS
  1801  LYENQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1671 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 37 nTPM
liver: 32 nTPM
skin: 27 nTPM
salivary gland: 25 nTPM
thyroid gland: 25 nTPM
esophagus: 24 nTPM

Single-cell type

colonocytes: 387 nCPM
enterocytes: 377 nCPM
esophageal suprabasal cells: 259 nCPM
rod photoreceptor cells: 257 nCPM
prostatic hillock cells: 252 nCPM
ependymal cells: 248 nCPM

Immune cell

gdT-cell: 1.8 nTPM
memory CD8 T-cell: 1.3 nTPM
naive CD8 T-cell: 0.8 nTPM
memory CD4 T-cell: 0.5 nTPM
NK-cell: 0.4 nTPM
total PBMC: 0.3 nTPM

Brain region

hippocampal formation: 60 nTPM
cerebral cortex: 54 nTPM
basal ganglia: 45 nTPM
hypothalamus: 45 nTPM
amygdala: 43 nTPM
thalamus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.82
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of KIAA1671 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1671 as an antibody target. Whether an autoantibody or antibody against KIAA1671 could matter depends on whether native KIAA1671 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1671 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA1671 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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