Seroatlas · Human Serome Atlas

ARHGAP11A

Rho GTPase-activating protein 11A

Also known as: KIAA0013, RHGBA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P4F7
Gene
ARHGAP11A
Ensembl
ENSG00000198826
Chromosome
15
Canonical length
1023 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

Canonical amino-acid sequenceUniProt

1023 residues, UniProt reviewed canonical sequence.

>Q6P4F7|ARHGAP11A
     1  MWDQRLVRLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP FNALPHSAVP
    61  EYGHIPSFLV DACTSLEDHI HTEGLFRKSG SVIRLKALKN KVDHGEGCLS SAPPCDIAGL
   121  LKQFFRELPE PILPADLHEA LLKAQQLGTE EKNKATLLLS CLLADHTVHV LRYFFNFLRN
   181  VSLRSSENKM DSSNLAVIFA PNLLQTSEGH EKMSSNTEKK LRLQAAVVQT LIDYASDIGR
   241  VPDFILEKIP AMLGIDGLCA TPSLEGFEEG EYETPGEYKR KRRQSVGDFV SGALNKFKPN
   301  RTPSITPQEE RIAQLSESPV ILTPNAKRTL PVDSSHGFSS KKRKSIKHNF NFELLPSNLF
   361  NSSSTPVSVH IDTSSEGSSQ SSLSPVLIGG NHLITAGVPR RSKRIAGKKV CRVESGKAGC
   421  FSPKISHKEK VRRSLRLKFN LGKNGREVNG CSGVNRYESV GWRLANQQSL KNRIESVKTG
   481  LLFSPDVDEK LPKKGSEKIS KSEETLLTPE RLVGTNYRMS WTGPNNSSFQ EVDANEASSM
   541  VENLEVENSL EPDIMVEKSP ATSCELTPSN LNNKHNSNIT SSPLSGDENN MTKETLVKVQ
   601  KAFSESGSNL HALMNQRQSS VTNVGKVKLT EPSYLEDSPE ENLFETNDLT IVESKEKYEH
   661  HTGKGEKCFS ERDFSPLQTQ TFNRETTIKC YSTQMKMEHE KDIHSNMPKD YLSKQEFSSD
   721  EEIKKQQSPK DKLNNKLKEN ENMMEGNLPK CAAHSKDEAR SSFSQQSTCV VTNLSKPRPM
   781  RIAKQQSLET CEKTVSESSQ MTEHRKVSDH IQWFNKLSLN EPNRIKVKSP LKFQRTPVRQ
   841  SVRRINSLLE YSRQPTGHKL ASLGDTASPL VKSVSCDGAL SSCIESASKD SSVSCIKSGP
   901  KEQKSMSCEE SNIGAISKSS MELPSKSFLK MRKHPDSVNA SLRSTTVYKQ KILSDGQVKV
   961  PLDDLTNHDI VKPVVNNNMG ISSGINNRVL RRPSERGRAW YKGSPKHPIG KTQLLPTSKP
  1021  VDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 24 nTPM
  • bone marrow: 23 nTPM
  • tonsil: 13 nTPM
  • lymph node: 12 nTPM
  • rectum: 8.2 nTPM
  • testis: 7.6 nTPM

Single-cell type

  • monocyte progenitors: 4.7 nCPM
  • erythrocyte progenitors: 3.4 nCPM
  • megakaryocyte progenitors: 3.1 nCPM
  • microglia: 2.1 nCPM
  • papillary tip epithelial cells: 2 nCPM
  • neutrophil progenitors: 1.9 nCPM

Immune cell

  • memory CD4 T-cell: 0.9 nTPM
  • eosinophil: 0.8 nTPM
  • memory CD8 T-cell: 0.8 nTPM
  • T-reg: 0.7 nTPM
  • gdT-cell: 0.5 nTPM
  • intermediate monocyte: 0.4 nTPM

Brain region

  • midbrain: 3.8 nTPM
  • white matter: 3.6 nTPM
  • pons: 3.2 nTPM
  • spinal cord: 3.1 nTPM
  • medulla oblongata: 3 nTPM
  • basal ganglia: 2.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARHGAP11A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 165 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
0.01
DepMap mean gene effect
-0.32
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP11A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP11A as an antibody target. Whether an autoantibody or antibody against ARHGAP11A could matter depends on whether native ARHGAP11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP11A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGAP11A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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