Seroatlas · Human Serome Atlas

DCTN6

Dynactin subunit 6

Also known as: DCTN6_HUMAN, WS-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00399
Gene: DCTN6
Ensembl: ENSG00000104671
Chromosome: 8
Canonical length: 190 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>O00399|DCTN6
     1  MAEKTQKSVK IAPGAVVCVE SEIRGDVTIG PRTVIHPKAR IIAEAGPIVI GEGNLIEEQA
    61  LIINAYPDNI TPDTEDPEPK PMIIGTNNVF EVGCYSQAMK MGDNNVIESK AYVGRNVILT
   121  SGCIIGACCN LNTFEVIPEN TVIYGADCLR RVQTERPQPQ TLQLDFLMKI LPNYHHLKKT
   181  MKGSSTPVKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCTN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 79 nTPM
heart muscle: 71 nTPM
midbrain: 69 nTPM
parathyroid gland: 68 nTPM
amygdala: 65 nTPM
cerebral cortex: 63 nTPM

Single-cell type

syncytiotrophoblasts: 275 nCPM
esophageal apical cells: 163 nCPM
parietal cells: 141 nCPM
decidual stromal cells: 141 nCPM
oocytes: 134 nCPM
extravillous trophoblasts: 120 nCPM

Immune cell

plasmacytoid DC: 21 nTPM
basophil: 17 nTPM
myeloid DC: 16 nTPM
non-classical monocyte: 16 nTPM
intermediate monocyte: 16 nTPM
classical monocyte: 14 nTPM

Brain region

white matter: 66 nTPM
hypothalamus: 60 nTPM
cerebral cortex: 57 nTPM
spinal cord: 56 nTPM
cerebellum: 53 nTPM
medulla oblongata: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.06
gnomAD missense Z: 0.54
DepMap mean gene effect: -1.2
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitotic spindle organization

Molecular functions

dynein complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Trimeric LpxA-like superfamily
Dynactin subunit 6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCTN6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCTN6 as an antibody target. Whether an autoantibody or antibody against DCTN6 could matter depends on whether native DCTN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCTN6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCTN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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