Seroatlas · Human Serome Atlas

PPP1R18

Phostensin

Also known as: KIAA1949, phostensin, PPR18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NYC8
Gene: PPP1R18
Ensembl: ENSG00000146112
Chromosome: 6
Canonical length: 613 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

613 residues, UniProt reviewed canonical sequence.

>Q6NYC8|PPP1R18
     1  MATIPDWKLQ LLARRRQEEA SVRGREKAER ERLSQMPAWK RGLLERRRAK LGLSPGEPSP
    61  VLGTVEAGPP DPDESAVLLE AIGPVHQNRF IRQERQQQQQ QQQRSEELLA ERKPGPLEAR
   121  ERRPSPGEMR DQSPKGRESR EERLSPRETR ERRLGIGGAQ ELSLRPLEAR DWRQSPGEVG
   181  DRSSRLSEAW KWRLSPGETP ERSLRLAESR EQSPRRKEVE SRLSPGESAY QKLGLTEAHK
   241  WRPDSRESQE QSLVQLEATE WRLRSGEERQ DYSEECGRKE EWPVPGVAPK ETAELSETLT
   301  REAQGNSSAG VEAAEQRPVE DGERGMKPTE GWKWTLNSGK AREWTPRDIE AQTQKPEPPE
   361  SAEKLLESPG VEAGEGEAEK EEAGAQGRPL RALQNCCSVP SPLPPEDAGT GGLRQQEEEA
   421  VELQPPPPAP LSPPPPAPTA PQPPGDPLMS RLFYGVKAGP GVGAPRRSGH TFTVNPRRSV
   481  PPATPATPTS PATVDAAVPG AGKKRYPTAE EILVLGGYLR LSRSCLAKGS PERHHKQLKI
   541  SFSETALETT YQYPSESSVL EELGPEPEVP SAPNPPAAQP DDEEDEEELL LLQPELQGGL
   601  RTKALIVDES CRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

spleen: 74 nTPM
lymph node: 71 nTPM
bone marrow: 53 nTPM
blood vessel: 52 nTPM
lung: 52 nTPM
thymus: 50 nTPM

Single-cell type

microglia: 43 nCPM
oligodendrocyte progenitor cells: 18 nCPM
nk-cells: 7.2 nCPM
bergmann glia: 4.5 nCPM
late spermatids: 4.1 nCPM
papillary tip epithelial cells: 4 nCPM

Immune cell

eosinophil: 216 nTPM
neutrophil: 170 nTPM
gdT-cell: 44 nTPM
basophil: 43 nTPM
memory CD8 T-cell: 42 nTPM
T-reg: 40 nTPM

Brain region

medulla oblongata: 33 nTPM
thalamus: 30 nTPM
pons: 29 nTPM
spinal cord: 25 nTPM
white matter: 25 nTPM
cerebral cortex: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

cytoskeleton

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R18 as an antibody target. Whether an autoantibody or antibody against PPP1R18 could matter depends on whether native PPP1R18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...