Seroatlas · Human Serome Atlas

FNDC11

Fibronectin type III domain-containing protein 11

Also known as: C20orf195, FND11_HUMAN, MGC5356

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVV2
Gene: FNDC11
Ensembl: ENSG00000125531
Chromosome: 20
Canonical length: 318 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Aggresome

OverviewNCBI Gene

No narrative summary is available for FNDC11 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q9BVV2|FNDC11
     1  MSTHVAGLGL DKMKLGNPQS FLDQEEADDQ QLLEPEAWKT YTERRNALRE FLTSDLSPHL
    61  LKRHHARMQL LRKCSYYIEV LPKHLALGDQ NPLVLPSALF QLIDPWKFQR MKKVGTAQTK
   121  IQLLLLGDLL EQLDHGRAEL DALLRSPDPR PFLADWALVE RRLADVSAVM DSFLTMMVPG
   181  RLHVKHRLVS DVSATKIPHI WLMLSTKMPV VFDRKASAAH QDWARLRWFV TIQPATSEQY
   241  ELRFRLLDPR TQQECAQCGV IPVAACTFDV RNLLPNRSYK FTIKRAETST LVYEPWRDSL
   301  TLHTKPEPLE GPALSHSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNDC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 106 nTPM

Expression across tissuesHPA

Tissue

testis: 106 nTPM
epididymis: 2.2 nTPM
kidney: 1.2 nTPM
fallopian tube: 1.1 nTPM
hypothalamus: 1 nTPM
pituitary gland: 1 nTPM

Single-cell type

early spermatids: 1,355 nCPM
late primary spermatocytes: 676 nCPM
late spermatids: 203 nCPM
respiratory ciliated cells: 35 nCPM
epididymal principal cells: 15 nCPM
fallopian tube ciliated cells: 12 nCPM

Immune cell

naive B-cell: 3.3 nTPM
memory B-cell: 1.5 nTPM
eosinophil: 0.5 nTPM
T-reg: 0.4 nTPM
memory CD8 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM

Brain region

hypothalamus: 2.4 nTPM
medulla oblongata: 1.3 nTPM
midbrain: 1.3 nTPM
spinal cord: 0.9 nTPM
choroid plexus: 0.8 nTPM
amygdala: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Fibronectin type III
Fibronectin type III superfamily
Fibronectin type III domain-containing protein 11
DUF5581, Fn3-like domain
DUF5581, N-terminal domain
Family of unknown function (DUF5581) Fn3-like domain
Family of unknown function (DUF5581) N-terminal domain

InteractionsUniProt · HPA

Protein binding partners of FNDC11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNDC11 as an antibody target. Whether an autoantibody or antibody against FNDC11 could matter depends on whether native FNDC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNDC11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FNDC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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