Seroatlas · Human Serome Atlas

SRI

Sorcin

Also known as: SORCN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30626
Gene
SRI
Ensembl
ENSG00000075142
Chromosome
7
Canonical length
198 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>P30626|SRI
     1  MAYPGHPGAG GGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID ADELQRCLTQ
    61  SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA VLNGWRQHFI SFDTDRSGTV
   121  DPQELQKALT TMGFRLSPQA VNSIAKRYST NGKITFDDYI ACCVKLRALT DSFRRRDTAQ
   181  QGVVNFPYDD FIQCVMSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
530 nTPM

Expression across tissuesHPA

Tissue

  • colon: 530 nTPM
  • rectum: 419 nTPM
  • small intestine: 237 nTPM
  • basal ganglia: 211 nTPM
  • cerebral cortex: 195 nTPM
  • midbrain: 182 nTPM

Single-cell type

  • extravillous trophoblasts: 2,164 nCPM
  • colonocytes: 1,442 nCPM
  • enterocytes: 1,216 nCPM
  • respiratory ciliated cells: 619 nCPM
  • enteric transient amplifying cells: 605 nCPM
  • fallopian tube ciliated cells: 594 nCPM

Immune cell

  • basophil: 623 nTPM
  • eosinophil: 583 nTPM
  • non-classical monocyte: 264 nTPM
  • NK-cell: 225 nTPM
  • intermediate monocyte: 218 nTPM
  • total PBMC: 217 nTPM

Brain region

  • white matter: 176 nTPM
  • hypothalamus: 170 nTPM
  • medulla oblongata: 167 nTPM
  • spinal cord: 158 nTPM
  • cerebral cortex: 151 nTPM
  • midbrain: 151 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRI.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 62 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.46
gnomAD pLI
0
gnomAD missense Z
0.01
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRI as an antibody target. Whether an autoantibody or antibody against SRI could matter depends on whether native SRI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRI is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRI. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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