Seroatlas · Human Serome Atlas

TP53RK

EKC/KEOPS complex subunit TP53RK

Also known as: BUD32, C20orf64, dJ101A2.2, Nori-2p, prpk, PRPK_HUMAN, TPRKB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96S44
Gene
TP53RK
Ensembl
ENSG00000172315
Chromosome
20
Canonical length
253 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q96S44|TP53RK
     1  MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG RFQGRAAVIK
    61  HRFPKGYRHP ALEARLGRRR TVQEARALLR CRRAGISAPV VFFVDYASNC LYMEEIEGSV
   121  TVRDYIQSTM ETEKTPQGLS NLAKTIGQVL ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV
   181  LIDFGLSFIS ALPEDKGVDL YVLEKAFLST HPNTETVFEA FLKSYSTSSK KARPVLKKLD
   241  EVRLRGRKRS MVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TP53RK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 12 nTPM
  • testis: 12 nTPM
  • tonsil: 11 nTPM
  • lymph node: 10 nTPM
  • urinary bladder: 9.9 nTPM
  • skin: 9.7 nTPM

Single-cell type

  • late primary spermatocytes: 227 nCPM
  • early spermatids: 215 nCPM
  • syncytiotrophoblasts: 115 nCPM
  • extravillous trophoblasts: 93 nCPM
  • esophageal suprabasal cells: 63 nCPM
  • decidual stromal cells: 63 nCPM

Immune cell

  • basophil: 37 nTPM
  • eosinophil: 28 nTPM
  • T-reg: 26 nTPM
  • plasmacytoid DC: 25 nTPM
  • NK-cell: 23 nTPM
  • memory B-cell: 20 nTPM

Brain region

  • hypothalamus: 20 nTPM
  • white matter: 18 nTPM
  • basal ganglia: 17 nTPM
  • medulla oblongata: 17 nTPM
  • midbrain: 17 nTPM
  • cerebral cortex: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TP53RK.

Disease | AllUniProt

Conditions TP53RK is implicated in, by any mechanism.

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 118 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
-0.83
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TP53RK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TP53RK as an antibody target. Whether an autoantibody or antibody against TP53RK could matter depends on whether native TP53RK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TP53RK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TP53RK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TP53RK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...