Seroatlas · Human Serome Atlas

BEX2

Protein BEX2

Also known as: BEX2_HUMAN, DJ79P11.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXY8
Gene: BEX2
Ensembl: ENSG00000133134
Chromosome: X
Canonical length: 128 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q9BXY8|BEX2
     1  MESKEERALN NLIVENVNQE NDEKDEKEQV ANKGEPLALP LNVSEYCVPR GNRRRFRVRQ
    61  PILQYRWDIM HRLGEPQARM REENMERIGE EVRQLMEKLR EKQLSHSLRA VSTDPPHHDH
   121  HDEFCLMP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 301 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 301 nTPM
hypothalamus: 284 nTPM
cerebral cortex: 277 nTPM
amygdala: 235 nTPM
hippocampal formation: 226 nTPM
cerebellum: 215 nTPM

Single-cell type

epididymal basal cells: 418 nCPM
epididymal efferent duct absorptive cells: 320 nCPM
epididymal principal cells: 239 nCPM
pancreatic islet cells: 221 nCPM
müller glia: 203 nCPM
breast myoepithelial cells: 171 nCPM

Immune cell

naive CD4 T-cell: 69 nTPM
NK-cell: 62 nTPM
memory B-cell: 53 nTPM
naive CD8 T-cell: 50 nTPM
memory CD4 T-cell: 44 nTPM
naive B-cell: 43 nTPM

Brain region

hypothalamus: 135 nTPM
cerebral cortex: 121 nTPM
basal ganglia: 94 nTPM
white matter: 87 nTPM
hippocampal formation: 86 nTPM
midbrain: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0.1
gnomAD missense Z: -0.01
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BEX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEX2 as an antibody target. Whether an autoantibody or antibody against BEX2 could matter depends on whether native BEX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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