Seroatlas · Human Serome Atlas

MAGOHB

Protein mago nashi homolog 2

Also known as: FLJ10292, MGN2, MGN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A72
Gene: MAGOHB
Ensembl: ENSG00000111196
Chromosome: 12
Canonical length: 148 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in nucleus. Part of U2-type catalytic step 1 spliceosome; U2-type precatalytic spliceosome; and exon-exon junction subcomplex mago-y14. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>Q96A72|MAGOHB
     1  MAVASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK EAYVHKSVME
    61  ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS FTTSKIGSLI DVNQSKDPEG
   121  LRVFYYLVQD LKCLVFSLIG LHFKIKPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGOHB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

liver: 13 nTPM
tonsil: 11 nTPM
epididymis: 11 nTPM
thymus: 10 nTPM
lymph node: 8.7 nTPM
breast: 8.6 nTPM

Single-cell type

extravillous trophoblasts: 146 nCPM
gastric progenitor cells: 117 nCPM
migrating cytotrophoblasts: 88 nCPM
megakaryocytes: 80 nCPM
cytotrophoblasts: 79 nCPM
esophageal basal cells: 76 nCPM

Immune cell

plasmacytoid DC: 33 nTPM
NK-cell: 20 nTPM
naive CD8 T-cell: 19 nTPM
memory CD8 T-cell: 16 nTPM
naive CD4 T-cell: 15 nTPM
MAIT T-cell: 15 nTPM

Brain region

cerebral cortex: 8.4 nTPM
cerebellum: 6 nTPM
white matter: 5.1 nTPM
basal ganglia: 4.9 nTPM
choroid plexus: 4.8 nTPM
amygdala: 4.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAGOHB.

Disease | ImmuneIEDB

Conditions an epitope on MAGOHB was assayed in.

head and neck squamous cell carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.33
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAGOHB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGOHB as an antibody target. Whether an autoantibody or antibody against MAGOHB could matter depends on whether native MAGOHB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGOHB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGOHB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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