Seroatlas · Human Serome Atlas

CORO1B

Coronin-1B

Also known as: COR1B_HUMAN, coronin-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BR76
Gene
CORO1B
Ensembl
ENSG00000172725
Chromosome
11
Canonical length
489 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

489 residues, UniProt reviewed canonical sequence.

>Q9BR76|CORO1B
     1  MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV IVEASGGGAF
    61  LVLPLSKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS GSEDCTVMVW QIPENGLTSP
   121  LTEPVVVLEG HTKRVGIIAW HPTARNVLLS AGCDNVVLIW NVGTAEELYR LDSLHPDLIY
   181  NVSWNHNGSL FCSACKDKSV RIIDPRRGTL VAEREKAHEG ARPMRAIFLA DGKVFTTGFS
   241  RMSERQLALW DPENLEEPMA LQELDSSNGA LLPFYDPDTS VVYVCGKGDS SIRYFEITEE
   301  PPYIHFLNTF TSKEPQRGMG SMPKRGLEVS KCEIARFYKL HERKCEPIVM TVPRKSDLFQ
   361  DDLYPDTAGP EAALEAEEWV SGRDADPILI SLREAYVPSK QRDLKISRRN VLSDSRPAMA
   421  PGSSHLGAPA STTTAADATP SGSLARAGEA GKLEEVMQEL RALRALVKEQ GDRICRLEEQ
   481  LGRMENGDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CORO1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 72 nTPM
  • stomach: 69 nTPM
  • blood vessel: 67 nTPM
  • prostate: 66 nTPM
  • salivary gland: 66 nTPM
  • spleen: 64 nTPM

Single-cell type

  • esophageal apical cells: 395 nCPM
  • extravillous trophoblasts: 343 nCPM
  • hofbauer cells: 331 nCPM
  • colonocytes: 245 nCPM
  • enterocytes: 239 nCPM
  • syncytiotrophoblasts: 186 nCPM

Immune cell

  • non-classical monocyte: 223 nTPM
  • intermediate monocyte: 213 nTPM
  • classical monocyte: 103 nTPM
  • myeloid DC: 79 nTPM
  • plasmacytoid DC: 61 nTPM
  • total PBMC: 58 nTPM

Brain region

  • medulla oblongata: 45 nTPM
  • white matter: 41 nTPM
  • thalamus: 40 nTPM
  • pons: 38 nTPM
  • spinal cord: 37 nTPM
  • basal ganglia: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
1.03
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CORO1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CORO1B as an antibody target. Whether an autoantibody or antibody against CORO1B could matter depends on whether native CORO1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CORO1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CORO1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CORO1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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