Seroatlas · Human Serome Atlas

ARPIN

Arpin

Also known as: ARPIN_HUMAN, C15orf38, MGC61550

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6K5
Gene: ARPIN
Ensembl: ENSG00000242498
Chromosome: 15
Canonical length: 226 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in directional locomotion; negative regulation of cell migration; and negative regulation of cellular component organization. Predicted to be located in lamellipodium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q7Z6K5|ARPIN
     1  MSRIYHDGAL RNKAVQSVRL PGAWDPAAHQ GGNGVLLEGE LIDVSRHSIL DTHGRKERYY
    61  VLYIRPSHIH RRKFDAKGNE IEPNFSATRK VNTGFLMSSY KVEAKGDTDR LTPEALKGLV
   121  NKPELLALTE SLTPDHTVAF WMPESEMEVM ELELGAGVRL KTRGDGPFLD SLAKLEAGTV
   181  TKCNFTGDGK TGASWTDNIM AQKCSKGAAA EIREQGDGAE DEEWDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARPIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

pancreas: 38 nTPM
small intestine: 16 nTPM
rectum: 16 nTPM
colon: 14 nTPM
duodenum: 14 nTPM
epididymis: 13 nTPM

Single-cell type

late spermatids: 151 nCPM
late primary spermatocytes: 31 nCPM
early spermatids: 26 nCPM
enterocytes: 22 nCPM
microglia: 19 nCPM
pancreatic acinar cells: 12 nCPM

Immune cell

classical monocyte: 5.3 nTPM
myeloid DC: 4.5 nTPM
intermediate monocyte: 2.9 nTPM
total PBMC: 1.3 nTPM
neutrophil: 0.7 nTPM
basophil: 0.5 nTPM

Brain region

cerebellum: 28 nTPM
medulla oblongata: 28 nTPM
thalamus: 26 nTPM
white matter: 26 nTPM
basal ganglia: 26 nTPM
hypothalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

lamellipodium

Protein domainsUniProt · Pfam · InterPro

Arpin
Arp2/3-interacting proteins Arpin

KeywordsUniProt

Cell projection

InteractionsUniProt · HPA

Protein binding partners of ARPIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARPIN as an antibody target. Whether an autoantibody or antibody against ARPIN could matter depends on whether native ARPIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARPIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARPIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...