Seroatlas · Human Serome Atlas

ARPC1A

Actin-related protein 2/3 complex subunit 1A

Also known as: ARC1A_HUMAN, Arc40, SOP2Hs, SOP2L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92747
Gene
ARPC1A
Ensembl
ENSG00000241685
Chromosome
7
Canonical length
370 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cell Junctions,Cytosol

OverviewNCBI Gene

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q92747|ARPC1A
     1  MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWVKAHELKE HNGHITGIDW
    61  APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI
   121  SVCYFESEND WWVSKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP
   181  ASTPWGSKMP FGQLMSEFGG SGTGGWVHGV SFSASGSRLA WVSHDSTVSV ADASKSVQVS
   241  TLKTEFLPLL SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDIPK QSIQRNMSAM
   301  ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG AMTIWDFKTL
   361  ESSIQGLRIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARPC1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
119 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 119 nTPM
  • heart muscle: 114 nTPM
  • stomach: 94 nTPM
  • choroid plexus: 92 nTPM
  • duodenum: 87 nTPM
  • cerebral cortex: 87 nTPM

Single-cell type

  • parietal cells: 99 nCPM
  • gastric chief cells: 86 nCPM
  • early primary spermatocytes: 66 nCPM
  • late primary spermatocytes: 60 nCPM
  • other brain neurons: 59 nCPM
  • vascular smooth muscle cells: 55 nCPM

Immune cell

  • basophil: 110 nTPM
  • eosinophil: 89 nTPM
  • non-classical monocyte: 87 nTPM
  • intermediate monocyte: 81 nTPM
  • neutrophil: 64 nTPM
  • classical monocyte: 50 nTPM

Brain region

  • hippocampal formation: 101 nTPM
  • hypothalamus: 92 nTPM
  • pons: 88 nTPM
  • choroid plexus: 87 nTPM
  • cerebral cortex: 86 nTPM
  • midbrain: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.74
gnomAD missense Z
2.65
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARPC1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARPC1A as an antibody target. Whether an autoantibody or antibody against ARPC1A could matter depends on whether native ARPC1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARPC1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARPC1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARPC1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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