Seroatlas · Human Serome Atlas

ARPC1B

Actin-related protein 2/3 complex subunit 1B

Also known as: ARC1B_HUMAN, ARC41, p40-ARC, p41-ARC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15143
Gene
ARPC1B
Ensembl
ENSG00000130429
Chromosome
7
Canonical length
372 aa
Protein class
Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>O15143|ARPC1B
     1  MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWTKVHELKE HNGQVTGIDW
    61  APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR CVRWAPNENK FAVGSGSRVI
   121  SICYFEQEND WWVCKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRIFS AYIKEVEERP
   181  APTPWGSKMP FGELMFESSS SCGWVHGVCF SASGSRVAWV SHDSTVCLAD ADKKMAVATL
   241  ASETLPLLAL TFITDNSLVA AGHDCFPVLF TYDAAAGMLS FGGRLDVPKQ SSQRGLTARE
   301  RFQNLDKKAS SEGGTAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM DGGMSIWDVK
   361  SLESALKDLK IK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARPC1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
288 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 288 nTPM
  • bone marrow: 195 nTPM
  • lymph node: 187 nTPM
  • appendix: 162 nTPM
  • lung: 155 nTPM
  • small intestine: 147 nTPM

Single-cell type

  • platelets: 2,880 nCPM
  • megakaryocytes: 1,756 nCPM
  • kupffer cells: 895 nCPM
  • extravillous trophoblasts: 824 nCPM
  • hofbauer cells: 687 nCPM
  • neutrophils: 501 nCPM

Immune cell

  • total PBMC: 4,165 nTPM
  • intermediate monocyte: 2,442 nTPM
  • classical monocyte: 2,386 nTPM
  • non-classical monocyte: 2,380 nTPM
  • myeloid DC: 2,045 nTPM
  • eosinophil: 1,966 nTPM

Brain region

  • thalamus: 35 nTPM
  • spinal cord: 30 nTPM
  • white matter: 30 nTPM
  • medulla oblongata: 28 nTPM
  • pons: 24 nTPM
  • choroid plexus: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARPC1B.

Disease | AllUniProt

Conditions ARPC1B is implicated in, by any mechanism.

  • Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia (IMD71) MIM:617718

Disease | GeneticClinVar

27 pathogenic / likely-pathogenic of 391 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on ARPC1B was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.01
gnomAD missense Z
1.18
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARPC1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARPC1B as an antibody target. Whether an autoantibody or antibody against ARPC1B could matter depends on whether native ARPC1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARPC1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARPC1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARPC1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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