Seroatlas · Human Serome Atlas

ANKRD28

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

Also known as: ANR28_HUMAN, CFAP79, FAP79, KIAA0379, PITK, PP6-ARS-A, PPP1R65

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15084
Gene: ANKRD28
Ensembl: ENSG00000206560
Chromosome: 3
Canonical length: 1053 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1053 residues, UniProt reviewed canonical sequence.

>O15084|ANKRD28
     1  MAFLKLRDQP SLVQAIFNGD PDEVRALIFK KEDVNFQDNE KRTPLHAAAY LGDAEIIELL
    61  ILSGARVNAK DSKWLTPLHR AVASCSEEAV QVLLKHSADV NARDKNWQTP LHIAAANKAV
   121  KCAEALVPLL SNVNVSDRAG RTALHHAAFS GHGEMVKLLL SRGANINAFD KKDRRAIHWA
   181  AYMGHIEVVK LLVSHGAEVT CKDKKSYTPL HAAASSGMIS VVKYLLDLGV DMNEPNAYGN
   241  TPLHVACYNG QDVVVNELID CGAIVNQKNE KGFTPLHFAA ASTHGALCLE LLVGNGADVN
   301  MKSKDGKTPL HMTALHGRFS RSQTIIQSGA VIDCEDKNGN TPLHIAARYG HELLINTLIT
   361  SGADTAKRGI HGMFPLHLAA LSGFSDCCRK LLSSGFDIDT PDDFGRTCLH AAAAGGNLEC
   421  LNLLLNTGAD FNKKDKFGRS PLHYAAANCN YQCLFALVGS GASVNDLDER GCTPLHYAAT
   481  SDTDGKCLEY LLRNDANPGI RDKQGYNAVH YSAAYGHRLC LQLIASETPL DVLMETSGTD
   541  MLSDSDNRAT ISPLHLAAYH GHHQALEVLV QSLLDLDVRN SSGRTPLDLA AFKGHVECVD
   601  VLINQGASIL VKDYILKRTP IHAAATNGHS ECLRLLIGNA EPQNAVDIQD GNGQTPLMLS
   661  VLNGHTDCVY SLLNKGANVD AKDKWGRTAL HRGAVTGHEE CVDALLQHGA KCLLRDSRGR
   721  TPIHLSAACG HIGVLGALLQ SAASMDANPA TADNHGYTAL HWACYNGHET CVELLLEQEV
   781  FQKTEGNAFS PLHCAVINDN EGAAEMLIDT LGASIVNATD SKGRTPLHAA AFTDHVECLQ
   841  LLLSHNAQVN SVDSTGKTPL MMAAENGQTN TVEMLVSSAS AELTLQDNSK NTALHLACSK
   901  GHETSALLIL EKITDRNLIN ATNAALQTPL HVAARNGLTM VVQELLGKGA SVLAVDENGY
   961  TPALACAPNK DVADCLALIL ATMMPVSSSS PLSSLTFNAI NRYTNTSKTV SFEALPIMRN
  1021  EPSSYCSFNN IGGEQEYLYT DVDELNDSDS ETY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

epididymis: 26 nTPM
skeletal muscle: 19 nTPM
tongue: 19 nTPM
cerebellum: 15 nTPM
parathyroid gland: 15 nTPM
pancreas: 13 nTPM

Single-cell type

plasma cells: 3,064 nCPM
mast cells: 1,229 nCPM
hematopoietic stem cells: 1,190 nCPM
thymocytes: 904 nCPM
innate lymphoid cells: 861 nCPM
megakaryocyte-erythroid progenitors: 732 nCPM

Immune cell

basophil: 17 nTPM
memory CD4 T-cell: 0.6 nTPM
MAIT T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 22 nTPM
white matter: 18 nTPM
medulla oblongata: 16 nTPM
basal ganglia: 15 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 2.39
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of focal adhesion assembly

Molecular functions

protein phosphatase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD28 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD28 as an antibody target. Whether an autoantibody or antibody against ANKRD28 could matter depends on whether native ANKRD28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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