Seroatlas · Human Serome Atlas

CLEC16A

Protein CLEC16A

Also known as: CL16A_HUMAN, Gop-1, KIAA0350

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2KHT3
Gene
CLEC16A
Ensembl
ENSG00000038532
Chromosome
16
Canonical length
1053 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

1053 residues, UniProt reviewed canonical sequence.

>Q2KHT3|CLEC16A
     1  MFGRSRSWVG GGHGKTSRNI HSLDHLKYLY HVLTKNTTVT EQNRNLLVET IRSITEILIW
    61  GDQNDSSVFD FFLEKNMFVF FLNILRQKSG RYVCVQLLQT LNILFENISH ETSLYYLLSN
   121  NYVNSIIVHK FDFSDEEIMA YYISFLKTLS LKLNNHTVHF FYNEHTNDFA LYTEAIKFFN
   181  HPESMVRIAV RTITLNVYKV SLDNQAMLHY IRDKTAVPYF SNLVWFIGSH VIELDDCVQT
   241  DEEHRNRGKL SDLVAEHLDH LHYLNDILII NCEFLNDVLT DHLLNRLFLP LYVYSLENQD
   301  KGGERPKISL PVSLYLLSQV FLIIHHAPLV NSLAEVILNG DLSEMYAKTE QDIQRSSAKP
   361  SIRCFIKPTE TLERSLEMNK HKGKRRVQKR PNYKNVGEEE DEEKGPTEDA QEDAEKAKGT
   421  EGGSKGIKTS GESEEIEMVI MERSKLSELA ASTSVQEQNT TDEEKSAAAT CSESTQWSRP
   481  FLDMVYHALD SPDDDYHALF VLCLLYAMSH NKGMDPEKLE RIQLPVPNAA EKTTYNHPLA
   541  ERLIRIMNNA AQPDGKIRLA TLELSCLLLK QQVLMSAGCI MKDVHLACLE GAREESVHLV
   601  RHFYKGEDIF LDMFEDEYRS MTMKPMNVEY LMMDASILLP PTGTPLTGID FVKRLPCGDV
   661  EKTRRAIRVF FMLRSLSLQL RGEPETQLPL TREEDLIKTD DVLDLNNSDL IACTVITKDG
   721  GMVQRFLAVD IYQMSLVEPD VSRLGWGVVK FAGLLQDMQV TGVEDDSRAL NITIHKPASS
   781  PHSKPFPILQ ATFIFSDHIR CIIAKQRLAK GRIQARRMKM QRIAALLDLP IQPTTEVLGF
   841  GLGSSTSTQH LPFRFYDQGR RGSSDPTVQR SVFASVDKVP GFAVAQCINQ HSSPSLSSQS
   901  PPSASGSPSG SGSTSHCDSG GTSSSSTPST AQSPADAPMS PELPKPHLPD QLVIVNETEA
   961  DSKPSKNVAR SAAVETASLS PSLVPARQPT ISLLCEDTAD TLSVESLTLV PPVDPHSLRS
  1021  LTGMPPLSTP AAACTEPVGE EAACAEPVGT AED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLEC16A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • testis: 44 nTPM
  • cerebellum: 20 nTPM
  • pituitary gland: 17 nTPM
  • cerebral cortex: 17 nTPM
  • skeletal muscle: 17 nTPM
  • choroid plexus: 16 nTPM

Single-cell type

  • podocytes: 588 nCPM
  • choroid plexus epithelial cells: 432 nCPM
  • sertoli cells: 338 nCPM
  • renal collecting duct intercalated cells: 331 nCPM
  • cone photoreceptor cells: 329 nCPM
  • ependymal cells: 281 nCPM

Immune cell

  • non-classical monocyte: 2.9 nTPM
  • basophil: 2.7 nTPM
  • naive B-cell: 2.7 nTPM
  • neutrophil: 2.5 nTPM
  • gdT-cell: 2.1 nTPM
  • naive CD4 T-cell: 2 nTPM

Brain region

  • choroid plexus: 73 nTPM
  • thalamus: 68 nTPM
  • cerebral cortex: 61 nTPM
  • cerebellum: 60 nTPM
  • midbrain: 56 nTPM
  • pons: 54 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLEC16A.

Disease | AllUniProt

Conditions CLEC16A is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.28
gnomAD missense Z
1.21
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • CLEC16A/TT9, N-terminal
  • CLEC16A/TT9
  • CLEC16A/TT9, C-terminal
  • Uncharacterised conserved protein
  • CLEC16A C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLEC16A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLEC16A as an antibody target. Whether an autoantibody or antibody against CLEC16A could matter depends on whether native CLEC16A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLEC16A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLEC16A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLEC16A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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