Small Leucine-Rich Proteoglycans
IPR050333
Definition
The small leucine-rich proteoglycan (SLRP) family is involved in various biological processes including collagen fiber assembly, cell adhesion, migration, and axon guidance. Members of this family play roles in maintaining tissue structure, such as anchoring basement membranes to connective tissue, affecting the rate of fibril formation, and regulating biomineralization. Some SLRPs are involved in modulating signaling pathways, such as TGF-beta and BMP signaling, which are critical for cartilage homeostasis and osteoarthritis pathogenesis. They also contribute to the organization of the extracellular matrix, particularly in the cornea, where they help maintain transparency and stromal matrix structure. Additionally, certain SLRPs participate in neuronal development, guiding neuron placement and synapse density regulation.
16 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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