DCN

Protein identityUniProt · HPA

UniProt accession

P07585

Gene

DCN

Ensembl

ENSG00000011465

Chromosome

12

Canonical length

359 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>P07585|DCN
     1  MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL GPVCPFRCQC
    61  HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV
   121  SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE
   181  LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS
   241  LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
   301  NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

3,363 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DCN.

Disease | AllUniProt

Conditions DCN is implicated in, by any mechanism.

• Corneal dystrophy, congenital stromal (CSCD) MIM:610048

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 102 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital stromal corneal dystrophy

ReferencesPubMed · IEDB

Publications for DCN from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.54

gnomAD pLI

0.31

gnomAD missense Z

0.8

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• animal organ morphogenesis
• negative regulation of angiogenesis
• negative regulation of endothelial cell migration
• negative regulation of vascular endothelial growth factor signaling pathway
• positive regulation of autophagy
• positive regulation of macroautophagy
• positive regulation of mitochondrial depolarization
• positive regulation of mitochondrial fission
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of transcription by RNA polymerase II

Molecular functions

• extracellular matrix binding
• extracellular matrix structural constituent conferring compression resistance
• glycosaminoglycan binding
• RNA binding

Cellular components

• extracellular matrix
• extracellular region
• extracellular space
• Golgi lumen
• lysosomal lumen

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat N-terminal domain
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
• Leucine-rich repeat domain superfamily
• Small Leucine-Rich Proteoglycans
• Leucine rich repeat N-terminal domain
• Leucine rich repeat

KeywordsUniProt

• Corneal dystrophy
• Disulfide bond
• Extracellular matrix
• Glycoprotein
• Leucine-rich repeat
• Proteoglycan
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of DCN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DPT