Seroatlas · Human Serome Atlas

OMD

Osteomodulin

Also known as: OMD_HUMAN, osteoadherin, SLRR2C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99983
Gene: OMD
Ensembl: ENSG00000127083
Chromosome: 9
Canonical length: 421 aa
Protein class: Predicted secreted proteins
Subcellular location: Nucleoli fibrillar center,Endoplasmic reticulum
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to be involved in cell adhesion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q99983|OMD
     1  MGFLSPIYVI FFFFGVKVHC QYETYQWDED YDQEPDDDYQ TGFPFRQNVD YGVPFHQYTL
    61  GCVSECFCPT NFPSSMYCDN RKLKTIPNIP MHIQQLYLQF NEIEAVTANS FINATHLKEI
   121  NLSHNKIKSQ KIDYGVFAKL PNLLQLHLEH NNLEEFPFPL PKSLERLLLG YNEISKLQTN
   181  AMDGLVNLTM LDLCYNYLHD SLLKDKIFAK MEKLMQLNLC SNRLESMPPG LPSSLMYLSL
   241  ENNSISSIPE KYFDKLPKLH TLRMSHNKLQ DIPYNIFNLP NIVELSVGHN KLKQAFYIPR
   301  NLEHLYLQNN EIEKMNLTVM CPSIDPLHYH HLTYIRVDQN KLKEPISSYI FFCFPHIHTI
   361  YYGEQRSTNG QTIQLKTQVF RRFPDDDDES EDHDDPDNAH ESPEQEGAEG HFDLHYYENQ
   421  E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OMD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 63 nTPM
ovary: 22 nTPM
heart muscle: 16 nTPM
cervix: 15 nTPM
breast: 12 nTPM
adipose tissue: 11 nTPM

Single-cell type

peritubular myoid cells: 173 nCPM
leydig cells: 141 nCPM
fibroblasts: 136 nCPM
decidual stromal cells: 121 nCPM
ovarian stromal cells: 80 nCPM
mesothelial cells: 72 nCPM

Immune cell

naive CD4 T-cell: 0.6 nTPM
naive CD8 T-cell: 0.5 nTPM
T-reg: 0.5 nTPM
memory B-cell: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM

Brain region

choroid plexus: 7.1 nTPM
cerebral cortex: 6.1 nTPM
basal ganglia: 5.2 nTPM
cerebellum: 4.4 nTPM
pons: 3.6 nTPM
amygdala: 3.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OMD.

Disease | ImmuneIEDB

Conditions an epitope on OMD was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell adhesion

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OMD as an antibody target. Whether an autoantibody or antibody against OMD could matter depends on whether native OMD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OMD is annotated as secreted, so native OMD circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OMD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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