FLRT2

Protein identityUniProt · HPA

UniProt accession

O43155

Gene

FLRT2

Ensembl

ENSG00000185070

Chromosome

14

Canonical length

660 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Secretome location

Intracellular and membrane

Quaternary structure

Homooligomer

OverviewNCBI Gene

This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

660 residues, UniProt reviewed canonical sequence.

>O43155|FLRT2
     1  MGLQTTKWPS HGAFFLKSWL IISLGLYSQV SKLLACPSVC RCDRNFVYCN ERSLTSVPLG
    61  IPEGVTVLYL HNNQINNAGF PAELHNVQSV HTVYLYGNQL DEFPMNLPKN VRVLHLQENN
   121  IQTISRAALA QLLKLEELHL DDNSISTVGV EDGAFREAIS LKLLFLSKNH LSSVPVGLPV
   181  DLQELRVDEN RIAVISDMAF QNLTSLERLI VDGNLLTNKG IAEGTFSHLT KLKEFSIVRN
   241  SLSHPPPDLP GTHLIRLYLQ DNQINHIPLT AFSNLRKLER LDISNNQLRM LTQGVFDNLS
   301  NLKQLTARNN PWFCDCSIKW VTEWLKYIPS SLNVRGFMCQ GPEQVRGMAV RELNMNLLSC
   361  PTTTPGLPLF TPAPSTASPT TQPPTLSIPN PSRSYTPPTP TTSKLPTIPD WDGRERVTPP
   421  ISERIQLSIH FVNDTSIQVS WLSLFTVMAY KLTWVKMGHS LVGGIVQERI VSGEKQHLSL
   481  VNLEPRSTYR ICLVPLDAFN YRAVEDTICS EATTHASYLN NGSNTASSHE QTTSHSMGSP
   541  FLLAGLIGGA VIFVLVVLLS VFCWHMHKKG RYTSQKWKYN RGRRKDDYCE AGTKKDNSIL
   601  EMTETSFQIV SLNNDQLLKG DFRLQPIYTP NGGINYTDCH IPNNMRYCNS SVPDLEHCHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLRT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

39 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.41

gnomAD pLI

0.82

gnomAD missense Z

1.28

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon guidance
• basement membrane organization
• fibroblast growth factor receptor signaling pathway
• heart morphogenesis
• positive regulation of synapse assembly
• regulation of neuron migration
• cell adhesion involved in heart morphogenesis

Molecular functions

• chemorepellent activity
• fibroblast growth factor receptor binding
• protein-macromolecule adaptor activity

Cellular components

• cell-cell junction
• endoplasmic reticulum membrane
• extracellular exosome
• extracellular matrix
• extracellular space
• focal adhesion
• glutamatergic synapse
• neuron projection
• plasma membrane
• postsynaptic membrane
• presynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat N-terminal domain
• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Fibronectin type III
• Immunoglobulin-like fold
• Leucine-rich repeat domain superfamily
• Fibronectin type III superfamily
• Small Leucine-Rich Proteoglycans
• Leucine rich repeat C-terminal domain
• Leucine rich repeat

KeywordsUniProt

• Cell adhesion
• Cell junction
• Cell membrane
• Developmental protein
• Disulfide bond
• Endoplasmic reticulum
• Extracellular matrix
• Glycoprotein
• Leucine-rich repeat
• Membrane
• Microsome
• Repeat
• Secreted
• Signal
• Synapse
• Synaptosome
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of FLRT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FGFR1
• FGFR2