KERA
Keratocan
Also known as: CNA2, KERA_HUMAN, SLRR2B
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O60938
- Gene
- KERA
- Ensembl
- ENSG00000139330
- Chromosome
- 12
- Canonical length
- 352 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted secreted proteins
- Secretome location
- Secreted to extracellular matrix
OverviewNCBI Gene
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]
Canonical amino-acid sequenceUniProt
352 residues, UniProt reviewed canonical sequence.
>O60938|KERA
1 MAGTICFIMW VLFITDTVWS RSVRQVYEVH DSDDWTIHDF ECPMECFCPP SFPTALYCEN
61 RGLKEIPAIP SRIWYLYLQN NLIETIPEKP FENATQLRWI NLNKNKITNY GIEKGALSQL
121 KKLLFLFLED NELEEVPSPL PRSLEQLQLA RNKVSRIPQG TFSNLENLTL LDLQNNKLVD
181 NAFQRDTFKG LKNLMQLNMA KNALRNMPPR LPANTMQLFL DNNSIEGIPE NYFNVIPKVA
241 FLRLNHNKLS DEGLPSRGFD VSSILDLQLS HNQLTKVPRI SAHLQHLHLD HNKIKSVNVS
301 VICPSPSMLP AERDSFSYGP HLRYLRLDGN EIKPPIPMAL MTCFRLLQAV IILocalizationUniProt · AlphaFold · HPA
Whether an antibody against KERA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 0.9 nTPM
Expression across tissuesHPA
Tissue
- gallbladder: 0.9 nTPM
- breast: 0.6 nTPM
- tongue: 0.6 nTPM
- fallopian tube: 0.5 nTPM
- colon: 0.4 nTPM
- ovary: 0.3 nTPM
Single-cell type
- fibroblasts: 2.8 nCPM
- endometrial ciliated cells: 1 nCPM
- fallopian tube ciliated cells: 0.6 nCPM
- neutrophils: 0.5 nCPM
- ocular epithelial cells: 0.3 nCPM
- enteric transient amplifying cells: 0.2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 0.1 nTPM
- pons: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about KERA.
Disease | AllUniProt
Conditions KERA is implicated in, by any mechanism.
- Cornea plana 2, autosomal recessive (CNA2) MIM:217300
Disease | GeneticClinVar
16 pathogenic / likely-pathogenic of 98 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Cornea plana 2
- KERA-related disorder
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.49
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.32
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KERA as an antibody target. Whether an autoantibody or antibody against KERA could matter depends on whether native KERA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KERA is annotated as secreted, so native KERA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label KERA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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