Seroatlas · Human Serome Atlas

FLRT1

Leucine-rich repeat transmembrane protein FLRT1

Also known as: FLRT1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZU1
Gene: FLRT1
Canonical length: 674 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for FLRT1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>Q9NZU1|FLRT1
     1  MVVAHPTATA TTTPTATVTA TVVMTTATMD LRDWLFLCYG LIAFLTEVID STTCPSVCRC
    61  DNGFIYCNDR GLTSIPADIP DDATTLYLQN NQINNAGIPQ DLKTKVNVQV IYLYENDLDE
   121  FPINLPRSLR ELHLQDNNVR TIARDSLARI PLLEKLHLDD NSVSTVSIEE DAFADSKQLK
   181  LLFLSRNHLS SIPSGLPHTL EELRLDDNRI STIPLHAFKG LNSLRRLVLD GNLLANQRIA
   241  DDTFSRLQNL TELSLVRNSL AAPPLNLPSA HLQKLYLQDN AISHIPYNTL AKMRELERLD
   301  LSNNNLTTLP RGLFDDLGNL AQLLLRNNPW FCGCNLMWLR DWVKARAAVV NVRGLMCQGP
   361  EKVRGMAIKD ITSEMDECFE TGPQGGVANA AAKTTASNHA SATTPQGSLF TLKAKRPGLR
   421  LPDSNIDYPM ATGDGAKTLA IHVKALTADS IRITWKATLP ASSFRLSWLR LGHSPAVGSI
   481  TETLVQGDKT EYLLTALEPK STYIICMVTM ETSNAYVADE TPVCAKAETA DSYGPTTTLN
   541  QEQNAGPMAS LPLAGIIGGA VALVFLFLVL GAICWYVHQA GELLTRERAY NRGSRKKDDY
   601  MESGTKKDNS ILEIRGPGLQ MLPINPYRAK EEYVVHTIFP SNGSSLCKAT HTIGYGTTRG
   661  YRDGGIPDID YSYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLRT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 6.9 nTPM
adrenal gland: 4.1 nTPM
basal ganglia: 3.9 nTPM
hippocampal formation: 3 nTPM
amygdala: 2.9 nTPM
colon: 2.6 nTPM

Single-cell type

myonuclei: 70 nCPM
cardiomyocytes: 56 nCPM
corticotrophs: 38 nCPM
oligodendrocyte progenitor cells: 29 nCPM
schwann cells: 22 nCPM
retinal amacrine cells: 20 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 32 nTPM
cerebral cortex: 32 nTPM
white matter: 29 nTPM
basal ganglia: 28 nTPM
midbrain: 24 nTPM
amygdala: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.36
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FLRT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FGFR1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FLRT1 as an antibody target. Whether an autoantibody or antibody against FLRT1 could matter depends on whether native FLRT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FLRT1 is annotated at the cell surface, where native FLRT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FLRT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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