Seroatlas · Human Serome Atlas

PODN

Podocan

Also known as: MGC24995, PCAN, PODN_HUMAN, PODOCAN, SLRR5A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5L7
Gene: PODN
Ensembl: ENSG00000174348
Chromosome: 1
Canonical length: 613 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

The protein encoded by this gene is a member of the small leucine-rich repeat protein family and contains an amino terminal CX3CXCX7C cysteine-rich cluster followed by a leucine-rich repeat domain. Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

613 residues, UniProt reviewed canonical sequence.

>Q7Z5L7|PODN
     1  MAQSRVLLLL LLLPPQLHLG PVLAVRAPGF GRSGGHSLSP EENEFAEEEP VLVLSPEEPG
    61  PGPAAVSCPR DCACSQEGVV DCGGIDLREF PGDLPEHTNH LSLQNNQLEK IYPEELSRLH
   121  RLETLNLQNN RLTSRGLPEK AFEHLTNLNY LYLANNKLTL APRFLPNALI SVDFAANYLT
   181  KIYGLTFGQK PNLRSVYLHN NKLADAGLPD NMFNGSSNVE VLILSSNFLR HVPKHLPPAL
   241  YKLHLKNNKL EKIPPGAFSE LSSLRELYLQ NNYLTDEGLD NETFWKLSSL EYLDLSSNNL
   301  SRVPAGLPRS LVLLHLEKNA IRSVDANVLT PIRSLEYLLL HSNQLREQGI HPLAFQGLKR
   361  LHTVHLYNNA LERVPSGLPR RVRTLMILHN QITGIGREDF ATTYFLEELN LSYNRITSPQ
   421  VHRDAFRKLR LLRSLDLSGN RLHTLPPGLP RNVHVLKVKR NELAALARGA LVGMAQLREL
   481  YLTSNRLRSR ALGPRAWVDL AHLQLLDIAG NQLTEIPEGL PESLEYLYLQ NNKISAVPAN
   541  AFDSTPNLKG IFLRFNKLAV GSVVDSAFRR LKHLQVLDIE GNLEFGDISK DRGRLGKEKE
   601  EEEEEEEEEE ETR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PODN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 178 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 178 nTPM
ovary: 166 nTPM
urinary bladder: 113 nTPM
breast: 112 nTPM
blood vessel: 109 nTPM
fallopian tube: 105 nTPM

Single-cell type

leydig cells: 371 nCPM
peritubular myoid cells: 326 nCPM
fibroblasts: 244 nCPM
fibro-adipogenic progenitors: 171 nCPM
hepatic stellate cells: 97 nCPM
ovarian stromal cells: 82 nCPM

Immune cell

gdT-cell: 5.1 nTPM
naive CD8 T-cell: 1.6 nTPM
memory CD8 T-cell: 1.4 nTPM
total PBMC: 0.8 nTPM
memory CD4 T-cell: 0.3 nTPM
basophil: 0 nTPM

Brain region

thalamus: 14 nTPM
midbrain: 14 nTPM
amygdala: 11 nTPM
pons: 9.9 nTPM
hypothalamus: 9.6 nTPM
basal ganglia: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

collagen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PODN as an antibody target. Whether an autoantibody or antibody against PODN could matter depends on whether native PODN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PODN is annotated as secreted, so native PODN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PODN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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