Seroatlas · Human Serome Atlas

FLRT3

Leucine-rich repeat transmembrane protein FLRT3

Also known as: FLRT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZU0
Gene
FLRT3
Ensembl
ENSG00000125848
Chromosome
20
Canonical length
649 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cell Junctions,Cytosol
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

649 residues, UniProt reviewed canonical sequence.

>Q9NZU0|FLRT3
     1  MISAAWSIFL IGTKIGLFLQ VAPLSVMAKS CPSVCRCDAG FIYCNDRFLT SIPTGIPEDA
    61  TTLYLQNNQI NNAGIPSDLK NLLKVERIYL YHNSLDEFPT NLPKYVKELH LQENNIRTIT
   121  YDSLSKIPYL EELHLDDNSV SAVSIEEGAF RDSNYLRLLF LSRNHLSTIP WGLPRTIEEL
   181  RLDDNRISTI SSPSLQGLTS LKRLVLDGNL LNNHGLGDKV FFNLVNLTEL SLVRNSLTAA
   241  PVNLPGTNLR KLYLQDNHIN RVPPNAFSYL RQLYRLDMSN NNLSNLPQGI FDDLDNITQL
   301  ILRNNPWYCG CKMKWVRDWL QSLPVKVNVR GLMCQAPEKV RGMAIKDLNA ELFDCKDSGI
   361  VSTIQITTAI PNTVYPAQGQ WPAPVTKQPD IKNPKLTKDH QTTGSPSRKT ITITVKSVTS
   421  DTIHISWKLA LPMTALRLSW LKLGHSPAFG SITETIVTGE RSEYLVTALE PDSPYKVCMV
   481  PMETSNLYLF DETPVCIETE TAPLRMYNPT TTLNREQEKE PYKNPNLPLA AIIGGAVALV
   541  TIALLALVCW YVHRNGSLFS RNCAYSKGRR RKDDYAEAGT KKDNSILEIR ETSFQMLPIS
   601  NEPISKEEFV IHTIFPPNGM NLYKNNHSES SSNRSYRDSG IPDSDHSHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLRT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 22 nTPM
  • lung: 17 nTPM
  • ovary: 16 nTPM
  • seminal vesicle: 13 nTPM
  • duodenum: 11 nTPM
  • stomach: 9.2 nTPM

Single-cell type

  • alveolar cells type 1: 360 nCPM
  • podocytes: 215 nCPM
  • alveolar cells type 2: 214 nCPM
  • transitional alveolar cells: 204 nCPM
  • basal prostatic cells: 168 nCPM
  • epididymal basal cells: 85 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 19 nTPM
  • cerebral cortex: 17 nTPM
  • hippocampal formation: 17 nTPM
  • thalamus: 11 nTPM
  • basal ganglia: 11 nTPM
  • white matter: 9.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FLRT3.

Disease | AllUniProt

Conditions FLRT3 is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 21 with or without anosmia (HH21) MIM:615271

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 117 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypogonadotropic hypogonadism 21 with or without anosmia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.22
gnomAD missense Z
1.86
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FLRT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FLRT3 as an antibody target. Whether an autoantibody or antibody against FLRT3 could matter depends on whether native FLRT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FLRT3 is annotated at the cell surface, where native FLRT3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FLRT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FLRT3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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