Seroatlas · Human Serome Atlas

LRRC24

Leucine-rich repeat-containing protein 24

Also known as: LRC24_HUMAN, LRRC14OS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q50LG9
Gene: LRRC24
Ensembl: ENSG00000254402
Chromosome: 8
Canonical length: 513 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane; extracellular matrix; and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>Q50LG9|LRRC24
     1  MALRAPALLP LLLLLLPLRA AGCPAACRCY SATVECGALR LRVVPLGIPP GTQTLFLQDN
    61  NIARLEPGAL APLAALRRLY LHNNSLRALE AGAFRAQPRL LELALTSNRL RGLRSGAFVG
   121  LAQLRVLYLA GNQLARLLDF TFLHLPRLQE LHLQENSIEL LEDQALAGLS SLALLDLSRN
   181  QLGTISREAL QPLASLQVLR LTENPWRCDC ALHWLGAWIK EGGQRLLTSR DRKIMCAEPP
   241  RLALQSLLDV SHSSLICIPP SVHVQPLELT ANLGEDLRVA CQASGYPQPL VTWRKVPQPR
   301  EGRPRAQAQL EGGLLGLGGH SASDTGSGML FLSNITLAHA GKYECEASNA GGAARVPFRL
   361  LVNASRQQPQ QPAQPPPPAA RPAGSEPRPE AGSMAFRALG VATQTAIAAA IALLALTALL
   421  LVAMICRRRR RRKKARGPPG EGALFVNDYL DGPCTFAQLE ELRDERGHEM FVINRSKPLF
   481  AEGPAEAPAD CGPEQGAGPG LRVPPPVAYE IHC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 13 nTPM
hypothalamus: 12 nTPM
cerebral cortex: 12 nTPM
prostate: 11 nTPM
cerebellum: 11 nTPM
basal ganglia: 10 nTPM

Single-cell type

late spermatids: 115 nCPM
retinal bipolar cells: 61 nCPM
rod photoreceptor cells: 36 nCPM
cone photoreceptor cells: 35 nCPM
pancreatic islet cells: 35 nCPM
cardiomyocytes: 30 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 24 nTPM
hypothalamus: 22 nTPM
midbrain: 22 nTPM
cerebral cortex: 19 nTPM
pons: 17 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: -0.68
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of synapse assembly

Molecular functions

signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC24 as an antibody target. Whether an autoantibody or antibody against LRRC24 could matter depends on whether native LRRC24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC24 is annotated at the cell surface, where native LRRC24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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