Seroatlas · Human Serome Atlas

PODNL1

Podocan-like protein 1

Also known as: FLJ23447, PONL1_HUMAN, SLRR5B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PEZ8
Gene: PODNL1
Ensembl: ENSG00000132000
Chromosome: 19
Canonical length: 512 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

An extracellular matrix structural constituent. Is active in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>Q6PEZ8|PODNL1
     1  MAESGLAMWP SLLLLLLLPG PPPVAGLEDA AFPHLGESLQ PLPRACPLRC SCPRVDTVDC
    61  DGLDLRVFPD NITRAAQHLS LQNNQLQELP YNELSRLSGL RTLNLHNNLI SSEGLPDEAF
   121  ESLTQLQHLC VAHNKLSVAP QFLPRSLRVA DLAANQVMEI FPLTFGEKPA LRSVYLHNNQ
   181  LSNAGLPPDA FRGSEAIATL SLSNNQLSYL PPSLPPSLER LHLQNNLISK VPRGALSRQT
   241  QLRELYLQHN QLTDSGLDAT TFSKLHSLEY LDLSHNQLTT VPAGLPRTLA ILHLGRNRIR
   301  QVEAARLHGA RGLRYLLLQH NQLGSSGLPA GALRPLRGLH TLHLYGNGLD RVPPALPRRL
   361  RALVLPHNHV AALGARDLVA TPGLTELNLA YNRLASARVH HRAFRRLRAL RSLDLAGNQL
   421  TRLPMGLPTG LRTLQLQRNQ LRMLEPEPLA GLDQLRELSL AHNRLRVGDI GPGTWHELQA
   481  LQVRHRLVSH TVPRAPPSPC LPCHVPNILV SW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PODNL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 13 nTPM
skin: 7.9 nTPM
vagina: 7.8 nTPM
cervix: 6.9 nTPM
hypothalamus: 6.5 nTPM
esophagus: 6.3 nTPM

Single-cell type

ependymal cells: 9.2 nCPM
other brain neurons: 5.7 nCPM
astrocytes: 2.9 nCPM
brain excitatory neurons: 2.3 nCPM
brain inhibitory neurons: 1.7 nCPM
peritubular myoid cells: 1.7 nCPM

Immune cell

myeloid DC: 0.3 nTPM
classical monocyte: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

medulla oblongata: 9.8 nTPM
midbrain: 9.7 nTPM
hypothalamus: 8.6 nTPM
pons: 6.8 nTPM
spinal cord: 6.3 nTPM
thalamus: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

extracellular matrix structural constituent

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PODNL1 as an antibody target. Whether an autoantibody or antibody against PODNL1 could matter depends on whether native PODNL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PODNL1 is annotated as secreted, so native PODNL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PODNL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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