Seroatlas · Human Serome Atlas

LRRC40

Leucine-rich repeat-containing protein 40

Also known as: FLJ20331, LRC40_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H9A6
Gene
LRRC40
Ensembl
ENSG00000066557
Chromosome
1
Canonical length
602 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

602 residues, UniProt reviewed canonical sequence.

>Q9H9A6|LRRC40
     1  MSRLKRIAGQ DLRAGFKAGG RDCGTSVPQG LLKAARKSGQ LNLSGRNLSE VPQCVWRINV
    61  DIPEEANQNL SFGATERWWE QTDLTKLIIS NNKLQSLTDD LRLLPALTVL DIHDNQLTSL
   121  PSAIRELENL QKLNVSHNKL KILPEEITNL RNLKCLYLQH NELTCISEGF EQLSNLEDLD
   181  LSNNHLTTVP ASFSSLSSLV RLNLSSNELK SLPAEINRMK RLKHLDCNSN LLETIPPELA
   241  GMESLELLYL RRNKLRFLPE FPSCSLLKEL HVGENQIEML EAEHLKHLNS ILVLDLRDNK
   301  LKSVPDEIIL LRSLERLDLS NNDISSLPYS LGNLHLKFLA LEGNPLRTIR REIISKGTQE
   361  VLKYLRSKIK DDGPSQSESA TETAMTLPSE SRVNIHAIIT LKILDYSDKQ ATLIPDEVFD
   421  AVKSNIVTSI NFSKNQLCEI PKRMVELKEM VSDVDLSFNK LSFISLELCV LQKLTFLDLR
   481  NNFLNSLPEE MESLVRLQTI NLSFNRFKML PEVLYRIFTL ETILISNNQV GSVDPQKMKM
   541  MENLTTLDLQ NNDLLQIPPE LGNCVNLRTL LLDGNPFRVP RAAILMKGTA AILEYLRDRI
   601  PT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • liver: 22 nTPM
  • bone marrow: 15 nTPM
  • duodenum: 14 nTPM
  • kidney: 13 nTPM
  • thymus: 13 nTPM
  • small intestine: 13 nTPM

Single-cell type

  • bergmann glia: 84 nCPM
  • cardiomyocytes: 61 nCPM
  • erythrocyte progenitors: 57 nCPM
  • neutrophil progenitors: 55 nCPM
  • myonuclei: 53 nCPM
  • monocyte progenitors: 53 nCPM

Immune cell

  • T-reg: 7.8 nTPM
  • NK-cell: 7.6 nTPM
  • MAIT T-cell: 7.3 nTPM
  • memory B-cell: 7.3 nTPM
  • naive B-cell: 6.8 nTPM
  • naive CD4 T-cell: 6.8 nTPM

Brain region

  • cerebellum: 19 nTPM
  • cerebral cortex: 16 nTPM
  • white matter: 16 nTPM
  • hypothalamus: 15 nTPM
  • basal ganglia: 15 nTPM
  • hippocampal formation: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.35
gnomAD pLI
0
gnomAD missense Z
0.18
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC40 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC40 as an antibody target. Whether an autoantibody or antibody against LRRC40 could matter depends on whether native LRRC40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC40. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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