Seroatlas · Human Serome Atlas

PRELP

Prolargin

Also known as: PRELP_HUMAN, prolargin, SLRR2A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51888
Gene
PRELP
Ensembl
ENSG00000188783
Chromosome
1
Canonical length
382 aa
Protein class
Plasma proteins, Predicted secreted proteins
Subcellular location
Endoplasmic reticulum,Plasma membrane
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>P51888|PRELP
     1  MRSPLCWLLP LLILASVAQG QPTRRPRPGT GPGRRPRPRP RPTPSFPQPD EPAEPTDLPP
    61  PLPPGPPSIF PDCPRECYCP PDFPSALYCD SRNLRKVPVI PPRIHYLYLQ NNFITELPVE
   121  SFQNATGLRW INLDNNRIRK IDQRVLEKLP GLVFLYMEKN QLEEVPSALP RNLEQLRLSQ
   181  NHISRIPPGV FSKLENLLLL DLQHNRLSDG VFKPDTFHGL KNLMQLNLAH NILRKMPPRV
   241  PTAIHQLYLD SNKIETIPNG YFKSFPNLAF IRLNYNKLTD RGLPKNSFNI SNLLVLHLSH
   301  NRISSVPAIN NRLEHLYLNN NSIEKINGTQ ICPNDLVAFH DFSSDLENVP HLRYLRLDGN
   361  YLKPPIPLDL MMCFRLLQSV VI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRELP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
546 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 546 nTPM
  • heart muscle: 203 nTPM
  • urinary bladder: 151 nTPM
  • endometrium: 130 nTPM
  • colon: 127 nTPM
  • ovary: 119 nTPM

Single-cell type

  • fibroblasts: 473 nCPM
  • melanocytes: 292 nCPM
  • hepatic stellate cells: 220 nCPM
  • peritubular myoid cells: 200 nCPM
  • vascular smooth muscle cells: 169 nCPM
  • ovarian stromal cells: 162 nCPM

Immune cell

  • basophil: 1.1 nTPM
  • neutrophil: 0.4 nTPM
  • naive B-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM

Brain region

  • choroid plexus: 37 nTPM
  • cerebral cortex: 37 nTPM
  • basal ganglia: 25 nTPM
  • amygdala: 21 nTPM
  • hippocampal formation: 19 nTPM
  • thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
gnomAD missense Z
0.74
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRELP as an antibody target. Whether an autoantibody or antibody against PRELP could matter depends on whether native PRELP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRELP is annotated as secreted, so native PRELP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRELP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRELP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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