Seroatlas · Human Serome Atlas

LRRTM4

Leucine-rich repeat transmembrane neuronal protein 4

Also known as: FLJ12568, LRRT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VH4
Gene
LRRTM4
Ensembl
ENSG00000176204
Chromosome
2
Canonical length
590 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable heparan sulfate proteoglycan binding activity. Predicted to be involved in regulation of synapse assembly. Predicted to act upstream of or within AMPA glutamate receptor clustering; positive regulation of synapse assembly; and regulation of presynaptic membrane organization. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in several cellular components, including GABA-ergic synapse; photoreceptor ribbon synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>Q86VH4|LRRTM4
     1  MGFHLITQLK GMSVVLVLLP TLLLVMLTGA QRACPKNCRC DGKIVYCESH AFADIPENIS
    61  GGSQGLSLRF NSIQKLKSNQ FAGLNQLIWL YLDHNYISSV DEDAFQGIRR LKELILSSNK
   121  ITYLHNKTFH PVPNLRNLDL SYNKLQTLQS EQFKGLRKLI ILHLRSNSLK TVPIRVFQDC
   181  RNLDFLDLGY NRLRSLSRNA FAGLLKLKEL HLEHNQFSKI NFAHFPRLFN LRSIYLQWNR
   241  IRSISQGLTW TWSSLHNLDL SGNDIQGIEP GTFKCLPNLQ KLNLDSNKLT NISQETVNAW
   301  ISLISITLSG NMWECSRSIC PLFYWLKNFK GNKESTMICA GPKHIQGEKV SDAVETYNIC
   361  SEVQVVNTER SHLVPQTPQK PLIIPRPTIF KPDVTQSTFE TPSPSPGFQI PGAEQEYEHV
   421  SFHKIIAGSV ALFLSVAMIL LVIYVSWKRY PASMKQLQQH SLMKRRRKKA RESERQMNSP
   481  LQEYYVDYKP TNSETMDISV NGSGPCTYTI SGSRECEMPH HMKPLPYYSY DQPVIGYCQA
   541  HQPLHVTKGY ETVSPEQDES PGLELGRDHS FIATIARSAA PAIYLERIAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRTM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 11 nTPM
  • retina: 6.1 nTPM
  • basal ganglia: 3.4 nTPM
  • hypothalamus: 3.4 nTPM
  • amygdala: 2.8 nTPM
  • hippocampal formation: 2.3 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 4,092 nCPM
  • bergmann glia: 2,939 nCPM
  • fibro-adipogenic progenitors: 2,593 nCPM
  • brain inhibitory neurons: 2,339 nCPM
  • other brain neurons: 2,303 nCPM
  • brain excitatory neurons: 1,982 nCPM

Immune cell

  • neutrophil: 1.6 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • NK-cell: 0.4 nTPM
  • memory B-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM

Brain region

  • cerebral cortex: 99 nTPM
  • white matter: 86 nTPM
  • basal ganglia: 82 nTPM
  • amygdala: 72 nTPM
  • midbrain: 62 nTPM
  • hippocampal formation: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.09
gnomAD missense Z
1.59
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRTM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRTM4 as an antibody target. Whether an autoantibody or antibody against LRRTM4 could matter depends on whether native LRRTM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRTM4 is annotated at the cell surface, where native LRRTM4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRTM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRTM4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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