Seroatlas · Human Serome Atlas

LUM

Lumican

Also known as: LDC, LUM_HUMAN, SLRR2D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51884
Gene
LUM
Ensembl
ENSG00000139329
Chromosome
12
Canonical length
338 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>P51884|LUM
     1  MSLSAFTLFL ALIGGTSGQY YDYDFPLSIY GQSSPNCAPE CNCPESYPSA MYCDELKLKS
    61  VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN LLENSKIKGR VFSKLKQLKK
   121  LHINHNNLTE SVGPLPKSLE DLQLTHNKIT KLGSFEGLVN LTFIHLQHNR LKEDAVSAAF
   181  KGLKSLEYLD LSFNQIARLP SGLPVSLLTL YLDNNKISNI PDEYFKRFNA LQYLRLSHNE
   241  LADSGIPGNS FNVSSLVELD LSYNKLKNIP TVNENLENYY LEVNQLEKFD IKSFCKILGP
   301  LSYSKIKHLR LDGNRISETS LPPDMYECLR VANEVTLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LUM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
692 nTPM

Expression across tissuesHPA

Tissue

  • gallbladder: 692 nTPM
  • placenta: 504 nTPM
  • urinary bladder: 454 nTPM
  • smooth muscle: 331 nTPM
  • endometrium: 282 nTPM
  • lung: 199 nTPM

Single-cell type

  • decidual stromal cells: 7,753 nCPM
  • fibroblasts: 1,386 nCPM
  • hepatic stellate cells: 910 nCPM
  • endometrial stromal cells: 705 nCPM
  • leydig cells: 229 nCPM
  • ovarian stromal cells: 180 nCPM

Immune cell

  • basophil: 12 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 8.1 nTPM
  • thalamus: 2 nTPM
  • medulla oblongata: 1.1 nTPM
  • hypothalamus: 1 nTPM
  • cerebral cortex: 0.9 nTPM
  • pons: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0.08
gnomAD missense Z
1.65
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LUM as an antibody target. Whether an autoantibody or antibody against LUM could matter depends on whether native LUM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LUM is annotated as secreted, so native LUM circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LUM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LUM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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