Forkhead box domain-containing protein
IPR050211
Definition
This family of proteins includes transcription factors that play key roles in various developmental processes, such as differentiation of hair follicles, pharyngeal arch development, and embryonic patterning. Members of this family are involved in the regulation of gene expression by binding to DNA consensus sequences and acting as either transcriptional activators or repressors. They are essential for the proper development and function of multiple tissues, including the liver, pancreas, lungs, and kidneys. Some proteins within this family are also implicated in the maintenance of cell viability and resistance to oxidative stress, as well as in the regulation of cell cycle and apoptosis. They are characterized by the presence of a forkhead box (FOX) domain, which is a conserved DNA-binding motif.
26 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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