Antigen-presenting and immune regulatory MHC class I-related
IPR050208
Definition
The protein family includes antigen-presenting molecules that display peptides or lipid antigens to T-cell receptors, contributing to immune surveillance and response. Members are involved in presenting foreign antigens, including microbial and tumor-derived peptides, to the immune system. Some act as ligands for receptors like KLRK1/NKG2D, mediating natural killer cell cytotoxicity. Others bind self and non-self glycolipids, presenting them to natural killer T-cells. The family also includes proteins that regulate humoral immunity by recycling IgG, extending its half-life, and transferring passive immunity. Additionally, some members bind to transferrin receptor, modulating iron uptake, while others are involved in stress-induced self-antigen recognition or immune regulation at the maternal-fetal interface. Overall, the family plays a crucial role in immune system regulation, pathogen defense, and maintaining homeostasis.
24 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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