AMP-binding enzyme domain superfamily
IPR045851
Definition
This is a small domain that is found C-terminal to [interpro:IPR000873] in ATP-dependent AMP-binding enzymes from eukaryotes, bacteria and archaea, including Acetyl-coenzyme A synthetase (Acs). In Acs, this domain undergoes a large rotation to allow for both half-reaction to occur. It shows a central β-sheet core that is flanked by α-helices PMID:12627952. This domain can be found multiple times in the protein or in other positions. For example, this domain is found at the N-terminal region in Flagellar M-ring proteins.
23 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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