TATDN1
Deoxyribonuclease TATDN1
Also known as: CDA11, TATD1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P1N9
- Gene
- TATDN1
- Ensembl
- ENSG00000147687
- Chromosome
- 8
- Canonical length
- 297 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable 3'-5'-DNA exonuclease activity. Predicted to be involved in DNA metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
297 residues, UniProt reviewed canonical sequence.
>Q6P1N9|TATDN1
1 MSRFKFIDIG INLTDPMFRG IYRGVQKHQD DLQDVIGRAV EIGVKKFMIT GGNLQDSKDA
61 LHLAQTNGMF FSTVGCHPTR CGEFEKNNPD LYLKELLNLA ENNKGKVVAI GECGLDFDRL
121 QFCPKDTQLK YFEKQFELSE QTKLPMFLHC RNSHAEFLDI MKRNRDRCVG GVVHSFDGTK
181 EAAAALIDLD LYIGFNGCSL KTEANLEVLK SIPSEKLMIE TDAPWCGVKS THAGSKYIRT
241 AFPTKKKWES GHCLKDRNEP CHIIQILEIM SAVRDEDPLE LANTLYNNTI KVFFPGILocalizationUniProt · AlphaFold · HPA
Whether an antibody against TATDN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.22
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 50 nTPM
- pancreas: 42 nTPM
- tongue: 41 nTPM
- ovary: 39 nTPM
- breast: 37 nTPM
- thyroid gland: 35 nTPM
Single-cell type
- cardiomyocytes: 285 nCPM
- gastric progenitor cells: 144 nCPM
- myonuclei: 128 nCPM
- gastric chief cells: 106 nCPM
- ovarian stromal cells: 106 nCPM
- decidual stromal cells: 104 nCPM
Immune cell
- basophil: 30 nTPM
- naive CD4 T-cell: 28 nTPM
- naive CD8 T-cell: 25 nTPM
- T-reg: 23 nTPM
- memory CD4 T-cell: 20 nTPM
- MAIT T-cell: 19 nTPM
Brain region
- white matter: 22 nTPM
- pons: 20 nTPM
- hypothalamus: 18 nTPM
- medulla oblongata: 17 nTPM
- spinal cord: 17 nTPM
- cerebellum: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.58
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.18
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- 3'-5' ssDNA/RNA exonuclease TatD-like
- Deoxyribonuclease, TatD-related, conserved site
- Metal-dependent hydrolase
- TatD related DNase
- TatD-type Metallo-dependent Hydrolase
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TATDN1 as an antibody target. Whether an autoantibody or antibody against TATDN1 could matter depends on whether native TATDN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TATDN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TATDN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...