Seroatlas · Human Serome Atlas

TATDN2

3'-5' RNA nuclease TATDN2

Also known as: KIAA0218, TATD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q93075
Gene: TATDN2
Ensembl: ENSG00000157014
Chromosome: 3
Canonical length: 761 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable metal ion binding activity and nuclease activity. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

761 residues, UniProt reviewed canonical sequence.

>Q93075|TATDN2
     1  MASERGKVKH NWSSTSEGCP RKRSCLREPC DVAPSSRPAQ RSASRSGGPS SPKRLKAQKE
    61  DDVACSRRLS WGSSRRRNNS SSSFSPHFLG PGVGGAASKG CLIRNTRGFL SSGGSPLRPA
   121  NASLEEMASL EEEACSLKVD SKDSSHNSTN SEFAAEAEGQ NDTIEEPNKV QKRKRDRLRD
   181  QGSTMIYLKA IQGILGKSMP KRKGEAATRA KPSAAEHPSH GEGPARSEGP AKTAEGAARS
   241  VTVTAAQKEK DATPEVSMEE DKTVPERSSF YDRRVVIDPQ EKPSEEPLGD RRTVIDKCSP
   301  PLEFLDDSDS HLEIQKHKDR EVVMEHPSSG SDWSDVEEIS TVRFSQEEPV SLKPSAVPEP
   361  SSFTTDYVMY PPHLYSSPWC DYASYWTSSP KPSSYPSTGS SSNDAAQVGK SSRSRMSDYS
   421  PNSTGSVQNT SRDMEASEEG WSQNSRSFRF SRSSEEREVK EKRTFQEEMP PRPCGGHASS
   481  SLPKSHLEPS LEEGFIDTHC HLDMLYSKLS FQGTFTKFRK IYSSSFPKEF QGCISDFCDP
   541  RTLTDCLWEE LLKEDLVWGA FGCHPHFARY YSESQERNLL QALRHPKAVA FGEMGLDYSY
   601  KCTTPVPEQH KVFERQLQLA VSLKKPLVIH CREADEDLLE IMKKFVPPDY KIHRHCFTGS
   661  YPVIEPLLKY FPNMSVGFTA VLTYSSAWEA REALRQIPLE RIIVETDAPY FLPRQVPKSL
   721  CQYAHPGLAL HTVREIARVK DQPLSLTLAA LRENTSRLYS L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TATDN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 33 nTPM
thymus: 30 nTPM
ovary: 22 nTPM
spleen: 21 nTPM
cerebral cortex: 21 nTPM
tonsil: 21 nTPM

Single-cell type

thymic myoid cells: 4.1 nCPM
epididymal clear cells: 2 nCPM
plasma cells: 1.9 nCPM
late spermatids: 1.6 nCPM
megakaryocyte progenitors: 1.5 nCPM
nk-cells: 1.5 nCPM

Immune cell

naive CD8 T-cell: 2.1 nTPM
T-reg: 1.8 nTPM
gdT-cell: 1.6 nTPM
MAIT T-cell: 1.6 nTPM
memory CD4 T-cell: 1.4 nTPM
naive B-cell: 1.4 nTPM

Brain region

cerebral cortex: 33 nTPM
basal ganglia: 32 nTPM
amygdala: 30 nTPM
hippocampal formation: 30 nTPM
hypothalamus: 30 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -0.05
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TATDN2 as an antibody target. Whether an autoantibody or antibody against TATDN2 could matter depends on whether native TATDN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TATDN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TATDN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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