Seroatlas · Human Serome Atlas

AMDHD2

N-acetylglucosamine-6-phosphate deacetylase

Also known as: CGI-14, NAGA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y303
Gene
AMDHD2
Ensembl
ENSG00000162066
Chromosome
16
Canonical length
409 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

Enables N-acetylglucosamine-6-phosphate deacetylase activity. Involved in negative regulation of UDP-N-acetylglucosamine biosynthetic process. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>Q9Y303|AMDHD2
     1  MRGEQGAAGA RVLQFTNCRI LRGGKLLRED LWVRGGRILD PEKLFFEERR VADERRDCGG
    61  RILAPGFIDV QINGGFGVDF SQATEDVGSG VALVARRILS HGVTSFCPTL VTSPPEVYHK
   121  VVPQIPVKSG GPHGAGVLGL HLEGPFISRE KRGAHPEAHL RSFEADAFQD LLATYGPLDN
   181  VRIVTLAPEL GRSHEVIRAL TARGICVSLG HSVADLRAAE DAVWSGATFI THLFNAMLPF
   241  HHRDPGIVGL LTSDRLPAGR CIFYGMIADG THTNPAALRI AHRAHPQGLV LVTDAIPALG
   301  LGNGRHTLGQ QEVEVDGLTA YVAGTKTLSG SIAPMDVCVR HFLQATGCSM ESALEAASLH
   361  PAQLLGLEKS KGTLDFGADA DFVVLDDSLH VQATYISGEL VWQADAARQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMDHD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 21 nTPM
  • testis: 18 nTPM
  • adrenal gland: 16 nTPM
  • kidney: 16 nTPM
  • small intestine: 15 nTPM
  • skin: 12 nTPM

Single-cell type

  • hofbauer cells: 223 nCPM
  • late primary spermatocytes: 129 nCPM
  • kupffer cells: 70 nCPM
  • enterocytes: 55 nCPM
  • early spermatids: 52 nCPM
  • syncytiotrophoblasts: 39 nCPM

Immune cell

  • non-classical monocyte: 10 nTPM
  • plasmacytoid DC: 9.9 nTPM
  • basophil: 9.6 nTPM
  • eosinophil: 9.6 nTPM
  • neutrophil: 8.4 nTPM
  • intermediate monocyte: 7.5 nTPM

Brain region

  • white matter: 9.9 nTPM
  • thalamus: 9.7 nTPM
  • cerebral cortex: 8.3 nTPM
  • medulla oblongata: 8.1 nTPM
  • basal ganglia: 7.5 nTPM
  • midbrain: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AMDHD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMDHD2 as an antibody target. Whether an autoantibody or antibody against AMDHD2 could matter depends on whether native AMDHD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMDHD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AMDHD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AMDHD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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