DPEP1

Protein identityUniProt · HPA

UniProt accession

P16444

Gene

DPEP1

Ensembl

ENSG00000015413

Chromosome

16

Canonical length

411 aa

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cell Junctions

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>P16444|DPEP1
     1  MWSGWWLWPL VAVCTADFFR DEAERIMRDS PVIDGHNDLP WQLLDMFNNR LQDERANLTT
    61  LAGTHTNIPK LRAGFVGGQF WSVYTPCDTQ NKDAVRRTLE QMDVVHRMCR MYPETFLYVT
   121  SSAGIRQAFR EGKVASLIGV EGGHSIDSSL GVLRALYQLG MRYLTLTHSC NTPWADNWLV
   181  DTGDSEPQSQ GLSPFGQRVV KELNRLGVLI DLAHVSVATM KATLQLSRAP VIFSHSSAYS
   241  VCASRRNVPD DVLRLVKQTD SLVMVNFYNN YISCTNKANL SQVADHLDHI KEVAGARAVG
   301  FGGDFDGVPR VPEGLEDVSK YPDLIAELLR RNWTEAEVKG ALADNLLRVF EAVEQASNLT
   361  QAPEEEPIPL DQLGGSCRTH YGYSSGASSL HRHWGLLLAS LAPLVLCLSL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPEP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

478 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

-1.11

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to calcium ion
• cellular response to nitric oxide
• glutathione catabolic process
• glutathione metabolic process
• homocysteine metabolic process
• inflammatory response
• leukotriene D4 catabolic process
• negative regulation of cell migration
• neutrophil chemotaxis
• proteolysis
• antibiotic metabolic process
• lactam catabolic process

Molecular functions

• beta-lactamase activity
• dipeptidase activity
• GPI anchor binding
• metallodipeptidase activity
• metalloexopeptidase activity
• modified amino acid binding
• zinc ion binding

Cellular components

• apical part of cell
• apical plasma membrane
• cell junction
• extracellular exosome
• extracellular space
• microvillus membrane
• nucleoplasm
• plasma membrane
• side of membrane

Protein domainsUniProt · Pfam · InterPro

• Membrane dipeptidase, active site
• Peptidase M19
• Metal-dependent hydrolase
• Membrane dipeptidase (Peptidase family M19)

KeywordsUniProt

• Cell membrane
• Cell projection
• Dipeptidase
• Disulfide bond
• Glycoprotein
• GPI-anchor
• Hydrolase
• Lipid metabolism
• Lipoprotein
• Membrane
• Metal-binding
• Metalloprotease
• Protease
• Signal
• Zinc

InteractionsUniProt · HPA

Protein binding partners of DPEP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• KIFBP