Seroatlas · Human Serome Atlas

DPEP3

Dipeptidase 3

Also known as: DPEP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4B8
Gene: DPEP3
Ensembl: ENSG00000141096
Chromosome: 16
Canonical length: 488 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q9H4B8|DPEP3
     1  MQPTGREGSR ALSRRYLRRL LLLLLLLLLR QPVTRAETTP GAPRALSTLG SPSLFTTPGV
    61  PSALTTPGLT TPGTPKTLDL RGRAQALMRS FPLVDGHNDL PQVLRQRYKN VLQDVNLRNF
   121  SHGQTSLDRL RDGLVGAQFW SASVSCQSQD QTAVRLALEQ IDLIHRMCAS YSELELVTSA
   181  EGLNSSQKLA CLIGVEGGHS LDSSLSVLRS FYVLGVRYLT LTFTCSTPWA ESSTKFRHHM
   241  YTNVSGLTSF GEKVVEELNR LGMMIDLSYA SDTLIRRVLE VSQAPVIFSH SAARAVCDNL
   301  LNVPDDILQL LKKNGGIVMV TLSMGVLQCN LLANVSTVAD HFDHIRAVIG SEFIGIGGNY
   361  DGTGRFPQGL EDVSTYPVLI EELLSRSWSE EELQGVLRGN LLRVFRQVEK VREESRAQSP
   421  VEAEFPYGQL STSCHSHLVP QNGHQATHLE VTKQPTNRVP WRSSNASPYL VPGLVAAATI
   481  PTFTQWLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPEP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

testis: 55 nTPM
spleen: 1.9 nTPM
bone marrow: 1.6 nTPM
small intestine: 0.8 nTPM
tongue: 0.5 nTPM
adipose tissue: 0.4 nTPM

Single-cell type

early primary spermatocytes: 428 nCPM
differentiating spermatogonia: 314 nCPM
late spermatids: 54 nCPM
undifferentiated spermatogonia: 23 nCPM
late primary spermatocytes: 23 nCPM
oocytes: 18 nCPM

Immune cell

neutrophil: 6.7 nTPM
NK-cell: 1.8 nTPM
eosinophil: 1 nTPM
naive B-cell: 0.5 nTPM
naive CD4 T-cell: 0.5 nTPM
intermediate monocyte: 0.4 nTPM

Brain region

choroid plexus: 0.7 nTPM
white matter: 0.6 nTPM
medulla oblongata: 0.4 nTPM
thalamus: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

dipeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPEP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TEX101

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPEP3 as an antibody target. Whether an autoantibody or antibody against DPEP3 could matter depends on whether native DPEP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPEP3 is annotated at the cell surface, where native DPEP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DPEP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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