Seroatlas · Human Serome Atlas

TATDN3

Deoxyribonuclease TATDN3

Also known as: TATD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17R31
Gene: TATDN3
Ensembl: ENSG00000203705
Chromosome: 1
Canonical length: 274 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Focal adhesion sites

OverviewNCBI Gene

Predicted to enable metal ion binding activity and nuclease activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>Q17R31|TATDN3
     1  MRAAGVGLVD CHCHLSAPDF DRDLDDVLEK AKKANVVALV AVAEHSGEFE KIMQLSERYN
    61  GFVLPCLGVH PVQGLPPEDQ RSVTLKDLDV ALPIIENYKD RLLAIGEVGL DFSPRFAGTG
   121  EQKEEQRQVL IRQIQLAKRL NLPVNVHSRS AGRPTINLLQ EQGAEKVLLH AFDGRPSVAM
   181  EGVRAGYFFS IPPSIIRSGQ KQKLVKQLPL TSICLETDSP ALGPEKQVRN EPWNISISAE
   241  YIAQVKGISV EEVIEVTTQN ALKLFPKLRH LLQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TATDN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 28 nTPM
tongue: 23 nTPM
heart muscle: 18 nTPM
parathyroid gland: 17 nTPM
choroid plexus: 17 nTPM
retina: 16 nTPM

Single-cell type

pdcs: 148 nCPM
kupffer cells: 76 nCPM
platelets: 71 nCPM
oligodendrocytes: 66 nCPM
microglia: 63 nCPM
myonuclei: 63 nCPM

Immune cell

plasmacytoid DC: 75 nTPM
non-classical monocyte: 65 nTPM
eosinophil: 60 nTPM
intermediate monocyte: 59 nTPM
myeloid DC: 46 nTPM
neutrophil: 42 nTPM

Brain region

white matter: 34 nTPM
hypothalamus: 29 nTPM
pons: 28 nTPM
basal ganglia: 28 nTPM
medulla oblongata: 28 nTPM
cerebral cortex: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TATDN3 as an antibody target. Whether an autoantibody or antibody against TATDN3 could matter depends on whether native TATDN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TATDN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TATDN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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