Seroatlas · Human Serome Atlas

DPEP2

Dipeptidase 2

Also known as: DPEP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4A9
Gene: DPEP2
Ensembl: ENSG00000167261
Chromosome: 16
Canonical length: 486 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>Q9H4A9|DPEP2
     1  MQPSGLEGPG TFGRWPLLSL LLLLLLLQPV TCAYTTPGPP RALTTLGAPR AHTMPGTYAP
    61  STTLSSPSTQ GLQEQARALM RDFPLVDGHN DLPLVLRQVY QKGLQDVNLR NFSYGQTSLD
   121  RLRDGLVGAQ FWSAYVPCQT QDRDALRLTL EQIDLIRRMC ASYSELELVT SAKALNDTQK
   181  LACLIGVEGG HSLDNSLSIL RTFYMLGVRY LTLTHTCNTP WAESSAKGVH SFYNNISGLT
   241  DFGEKVVAEM NRLGMMVDLS HVSDAVARRA LEVSQAPVIF SHSAARGVCN SARNVPDDIL
   301  QLLKKNGGVV MVSLSMGVIQ CNPSANVSTV ADHFDHIKAV IGSKFIGIGG DYDGAGKFPQ
   361  GLEDVSTYPV LIEELLSRGW SEEELQGVLR GNLLRVFRQV EKVQEENKWQ SPLEDKFPDE
   421  QLSSSCHSDL SRLRQRQSLT SGQELTEIPI HWTAKLPAKW SVSESSPHMA PVLAVVATFP
   481  VLILWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPEP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

spleen: 27 nTPM
bone marrow: 22 nTPM
lymph node: 18 nTPM
lung: 17 nTPM
tonsil: 17 nTPM
placenta: 13 nTPM

Single-cell type

neutrophils: 236 nCPM
syncytiotrophoblasts: 109 nCPM
kupffer cells: 106 nCPM
monocytes: 49 nCPM
b-cells: 49 nCPM
macrophages: 44 nCPM

Immune cell

eosinophil: 844 nTPM
basophil: 411 nTPM
neutrophil: 361 nTPM
non-classical monocyte: 127 nTPM
intermediate monocyte: 102 nTPM
classical monocyte: 83 nTPM

Brain region

white matter: 8.3 nTPM
medulla oblongata: 7.9 nTPM
thalamus: 6.5 nTPM
pons: 5.7 nTPM
spinal cord: 5.5 nTPM
midbrain: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPEP2 as an antibody target. Whether an autoantibody or antibody against DPEP2 could matter depends on whether native DPEP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPEP2 is annotated at the cell surface, where native DPEP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DPEP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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