Seroatlas · Human Serome Atlas

ACMSD

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Also known as: ACMSD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDX5
Gene
ACMSD
Ensembl
ENSG00000153086
Chromosome
2
Canonical length
336 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q8TDX5|ACMSD
     1  MKIDIHSHIL PKEWPDLKKR FGYGGWVQLQ HHSKGEAKLL KDGKVFRVVR ENCWDPEVRI
    61  REMDQKGVTV QALSTVPVMF SYWAKPEDTL NLCQLLNNDL ASTVVSYPRR FVGLGTLPMQ
   121  APELAVKEME RCVKELGFPG VQIGTHVNEW DLNAQELFPV YAAAERLKCS LFVHPWDMQM
   181  DGRMAKYWLP WLVGMPAETT IAICSMIMGG VFEKFPKLKV CFAHGGGAFP FTVGRISHGF
   241  SMRPDLCAQD NPMNPKKYLG SFYTDALVHD PLSLKLLTDV IGKDKVILGT DYPFPLGELE
   301  PGKLIESMEE FDEETKNKLK AGNALAFLGL ERKQFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACMSD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
152 nTPM

Expression across tissuesHPA

Tissue

  • liver: 152 nTPM
  • kidney: 132 nTPM
  • gallbladder: 6.7 nTPM
  • duodenum: 0.9 nTPM
  • salivary gland: 0.8 nTPM
  • retina: 0.4 nTPM

Single-cell type

  • proximal tubule cells: 388 nCPM
  • hepatocytes: 315 nCPM
  • cholangiocytes: 81 nCPM
  • cardiomyocytes: 71 nCPM
  • epididymal efferent duct absorptive cells: 39 nCPM
  • loop of henle epithelial cells: 37 nCPM

Immune cell

  • memory B-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • cerebellum: 3.5 nTPM
  • medulla oblongata: 3.4 nTPM
  • hypothalamus: 2.2 nTPM
  • cerebral cortex: 2.1 nTPM
  • pons: 1.9 nTPM
  • midbrain: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.01
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • L-tryptophan catabolic process
  • negative regulation of quinolinate biosynthetic process
  • picolinic acid biosynthetic process
  • regulation of 'de novo' NAD biosynthetic process from L-tryptophan
  • secondary metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACMSD as an antibody target. Whether an autoantibody or antibody against ACMSD could matter depends on whether native ACMSD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACMSD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACMSD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACMSD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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