Seroatlas · Human Serome Atlas

PTER

N-acetyltaurine hydrolase

Also known as: PTER_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BW5
Gene: PTER
Ensembl: ENSG00000165983
Chromosome: 10
Canonical length: 349 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables N-acetyltaurine hydrolase activity. Involved in epithelial cell differentiation and taurine metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q96BW5|PTER
     1  MSSLSGKVQT VLGLVEPSKL GRTLTHEHLA MTFDCCYCPP PPCQEAISKE PIVMKNLYWI
    61  QKNAYSHKEN LQLNQETEAI KEELLYFKAN GGGALVENTT TGISRDTQTL KRLAEETGVH
   121  IISGAGFYVD ATHSSETRAM SVEQLTDVLM NEILHGADGT SIKCGIIGEI GCSWPLTESE
   181  RKVLQATAHA QAQLGCPVII HPGRSSRAPF QIIRILQEAG ADISKTVMSH LDRTILDKKE
   241  LLEFAQLGCY LEYDLFGTEL LHYQLGPDID MPDDNKRIRR VRLLVEEGCE DRILVAHDIH
   301  TKTRLMKYGG HGYSHILTNV VPKMLLRGIT ENVLDKILIE NPKQWLTFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTER can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.2
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 41 nTPM
kidney: 29 nTPM
hippocampal formation: 26 nTPM
amygdala: 23 nTPM
stomach: 13 nTPM
liver: 13 nTPM

Single-cell type

proximal tubule cells: 145 nCPM
urothelial cells: 136 nCPM
pancreatic acinar cells: 126 nCPM
foveolar cells: 104 nCPM
renal collecting duct intercalated cells: 88 nCPM
alveolar cells type 2: 75 nCPM

Immune cell

T-reg: 14 nTPM
intermediate monocyte: 12 nTPM
non-classical monocyte: 10 nTPM
memory B-cell: 9.2 nTPM
memory CD4 T-cell: 8.8 nTPM
MAIT T-cell: 8.1 nTPM

Brain region

basal ganglia: 51 nTPM
hippocampal formation: 50 nTPM
cerebral cortex: 41 nTPM
amygdala: 32 nTPM
white matter: 20 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
gnomAD missense Z: -0.64
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding
N-acetyltaurine hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Metal-dependent hydrolase
Phosphotriesterase
Aryldialkylphosphatase, zinc-binding site
Phosphotriesterase family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTER as an antibody target. Whether an autoantibody or antibody against PTER could matter depends on whether native PTER is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTER is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTER as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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