Membrane-spanning 4-domains subfamily A

Definition

Membrane-spanning four-domains subfamily A (MS4A) includes B-cell-specific antigen CD20 (MS4A1), high affinity immunoglobulin epsilon receptor beta chain (MS4A2), hematopoietic-cell-specific protein HTm4 (MS4A3), and related proteins. These proteins share a similar structure with four transmembrane domains and have amino acid identities of 25-40% PMID:11245982. They are predominantly expressed in hematopoietic cells, but some can be found in other tissues including testis and brain [[cite:PMID:11162526], [cite:PMID:11401424]]. MS4A1 (B-lymphocyte antigen CD20) PMID:20038800, MS4A2 (high affinity IgE receptor subunit beta) [[cite:PMID:16272347], [cite:PMID:19001085]], and MS4A4B PMID:19752228 have been shown to have an important role in immunity. Several variants within the MS4A gene cluster have been implicated in Alzheimer's disease PMID:24981432.

14 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (14 proteins: gene, accession, name)

• MS4A1
• MS4A10
• MS4A12
• MS4A13
• MS4A14
• MS4A15
• MS4A18
• MS4A2
• MS4A3
• MS4A4A
• MS4A5
• MS4A6A
• MS4A7
• MS4A8