Seroatlas · Human Serome Atlas

MS4A10

Membrane-spanning 4-domains subfamily A member 10

Also known as: CD20L7, M4A10_HUMAN, MS4A9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PG2
Gene: MS4A10
Ensembl: ENSG00000172689
Chromosome: 11
Canonical length: 267 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>Q96PG2|MS4A10
     1  MKAEATVIPS RCARGLPSWQ VLSPVQPWQT SAPQNTTQPK LLAPHQHEKS QKKSSLLKEL
    61  GAFHITIALL HLVFGGYLAS IVKNLHLVVL KSWYPFWGAA SFLISGILAI TMKTFSKTYL
   121  KMLCLMTNLI SLFCVLSGLF VISKDLFLES PFESPIWRMY PNSTVHIQRL ELALLCFTVL
   181  ELFLPVPTAV TAWRGDCPSA KNDDACLVPN TPLHLKGLPV EPPPSYQSVI QGDAQHKQHQ
   241  RLREVKQVAP DTWIVTDGAA IWTQTAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

small intestine: 81 nTPM
duodenum: 69 nTPM
kidney: 0.7 nTPM
bone marrow: 0.3 nTPM
colon: 0.3 nTPM
skeletal muscle: 0.3 nTPM

Single-cell type

enterocytes: 340 nCPM
early spermatids: 6.8 nCPM
neuroendocrine cells: 4.6 nCPM
enteric transient amplifying cells: 4.3 nCPM
paneth cells: 3.9 nCPM
proximal tubule cells: 2.6 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 2 nTPM
cerebral cortex: 1.7 nTPM
choroid plexus: 1.7 nTPM
white matter: 1.7 nTPM
amygdala: 1.6 nTPM
basal ganglia: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MS4A10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NEDD4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A10 as an antibody target. Whether an autoantibody or antibody against MS4A10 could matter depends on whether native MS4A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A10 is annotated at the cell surface, where native MS4A10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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