Seroatlas · Human Serome Atlas

MS4A7

Membrane-spanning 4-domains subfamily A member 7

Also known as: CD20L4, CFFM4, MS4A7_HUMAN, MS4A8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZW8
Gene: MS4A7
Ensembl: ENSG00000166927
Chromosome: 11
Canonical length: 240 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q9GZW8|MS4A7
     1  MLLQSQTMGV SHSFTPKGIT IPQREKPGHM YQNEDYLQNG LPTETTVLGT VQILCCLLIS
    61  SLGAILVFAP YPSHFNPAIS TTLMSGYPFL GALCFGITGS LSIISGKQST KPFDLSSLTS
   121  NAVSSVTAGA GLFLLADSMV ALRTASQHCG SEMDYLSSLP YSEYYYPIYE IKDCLLTSVS
   181  LTGVLVVMLI FTVLELLLAA YSSVFWWKQL YSNNPGSSFS STQSQDHIQQ VKKSSSRSWI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 185 nTPM

Expression across tissuesHPA

Tissue

spleen: 185 nTPM
lung: 71 nTPM
liver: 62 nTPM
appendix: 48 nTPM
adipose tissue: 44 nTPM
gallbladder: 44 nTPM

Single-cell type

kupffer cells: 869 nCPM
macrophages: 216 nCPM
monocytes: 138 nCPM
hofbauer cells: 124 nCPM
cdc: 38 nCPM
microglia: 17 nCPM

Immune cell

non-classical monocyte: 1,496 nTPM
intermediate monocyte: 749 nTPM
classical monocyte: 189 nTPM
total PBMC: 138 nTPM
myeloid DC: 121 nTPM
memory B-cell: 23 nTPM

Brain region

thalamus: 38 nTPM
white matter: 37 nTPM
choroid plexus: 29 nTPM
medulla oblongata: 27 nTPM
pons: 24 nTPM
hypothalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor signaling pathway

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A7 as an antibody target. Whether an autoantibody or antibody against MS4A7 could matter depends on whether native MS4A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A7 is annotated at the cell surface, where native MS4A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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