Seroatlas · Human Serome Atlas

MS4A15

Membrane-spanning 4-domains subfamily A member 15

Also known as: M4A15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5U1
Gene: MS4A15
Ensembl: ENSG00000166961
Chromosome: 11
Canonical length: 240 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q8N5U1|MS4A15
     1  MSAAPASNGV FVVIPPNNAS GLCPPPAILP TSMCQPPGIM QFEEPPLGAQ TPRATQPPDL
    61  RPVETFLTGE PKVLGTVQIL IGLIHLGFGS VLLMVRRGHV GIFFIEGGVP FWGGACFIIS
   121  GSLSVAAEKN HTSCLVRSSL GTNILSVMAA FAGTAILLMD FGVTNRDVDR GYLAVLTIFT
   181  VLEFFTAVIA MHFGCQAIHA QASAPVIFLP NAFSADFNIP SPAASAPPAY DNVAYAQGVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MS4A15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

lung: 41 nTPM
thymus: 3.5 nTPM
breast: 2.1 nTPM
small intestine: 2 nTPM
tonsil: 1.7 nTPM
smooth muscle: 1.5 nTPM

Single-cell type

alveolar cells type 1: 116 nCPM
transitional alveolar cells: 100 nCPM
early spermatids: 6.1 nCPM
oocytes: 4.6 nCPM
migrating cytotrophoblasts: 4.5 nCPM
retinal ganglion cells: 3.9 nCPM

Immune cell

T-reg: 3.2 nTPM
memory CD4 T-cell: 0.8 nTPM
naive CD4 T-cell: 0.5 nTPM
naive CD8 T-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
total PBMC: 0.2 nTPM

Brain region

cerebral cortex: 1.8 nTPM
pons: 1.3 nTPM
white matter: 1.2 nTPM
cerebellum: 1 nTPM
basal ganglia: 0.9 nTPM
hypothalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MS4A15 as an antibody target. Whether an autoantibody or antibody against MS4A15 could matter depends on whether native MS4A15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MS4A15 is annotated at the cell surface, where native MS4A15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MS4A15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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